Molecular mechanisms regulating CD19, CD20 and CD22 gene expression

The CD19, CD20 and CD22 genes encode transmembrane proteins that are of vital importance to B-cell function. Similar to the immunoglobulin (lg) genes, they are expressed in a lineage-specific and developmentally regulated manner. Here, John Kehrl and colleagues describe how an understanding of the t...

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Veröffentlicht in:	Immunology today (Amsterdam. Regular ed.) 1994-09, Vol.15 (9), p.432-436
Hauptverfasser:	Kehrl, John H., Riva, Agostino, Wilson, Gaye Lynn, Thévenin, Claire
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - biosynthesis Antigens, CD - genetics Antigens, CD19 Antigens, CD20 Antigens, Differentiation, B-Lymphocyte - biosynthesis Antigens, Differentiation, B-Lymphocyte - genetics B-Lymphocytes - immunology Biological and medical sciences Cell Adhesion Molecules Cell Differentiation - immunology Fundamental and applied biological sciences. Psychology Gene Expression Regulation - immunology Lectins Molecular and cellular biology Molecular genetics Promoter Regions, Genetic - genetics Sialic Acid Binding Ig-like Lectin 2 Transcription. Transcription factor. Splicing. Rna processing
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Beschreibung
Zusammenfassung:	The CD19, CD20 and CD22 genes encode transmembrane proteins that are of vital importance to B-cell function. Similar to the immunoglobulin (lg) genes, they are expressed in a lineage-specific and developmentally regulated manner. Here, John Kehrl and colleagues describe how an understanding of the transcriptional regulation of the CD19, CD20 and CD22 genes is leading to valuable insights into some of the important molecular events that occur in B-cell development and differentiation.
ISSN:	0167-5699
DOI:	10.1016/0167-5699(94)90273-9