Cloning of a non-catalytic form of human trkB and distribution of messenger RNA for trkB in human brain

A truncated form of the human trkB gene has been cloned and sequenced. This gene is related to the trk family of tyrosine kinases, the products of which act as receptors for the neurotrophins. Of these, brain-derived neurotrophic factor and mammalian neurotrophin-4 are the known ligands for the TrkB...

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Veröffentlicht in:	Neuroscience 1994-06, Vol.60 (3), p.825-834
Hauptverfasser:	ALLEN, S. J, DAWBARN, D, ECKFORD, S. D, WILCOCK, G. K, ASHCROFT, M, COLEBROOK, S. M, FEENEY, R, MACGOWAN, S. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biochemistry and metabolism Biological and medical sciences Brain - embryology Brain Chemistry Catalysis Central nervous system Cloning, Molecular DNA Probes DNA, Complementary - genetics Fundamental and applied biological sciences. Psychology Hippocampus - chemistry Hippocampus - embryology Humans In Situ Hybridization, Fluorescence Mice Molecular Sequence Data Multigene Family Nerve Tissue Proteins - analysis Nerve Tissue Proteins - genetics Rats Receptor Protein-Tyrosine Kinases - analysis Receptor Protein-Tyrosine Kinases - genetics Receptor, Ciliary Neurotrophic Factor Receptor, trkA - analysis Receptor, trkA - genetics Receptor, trkB - analysis Receptor, trkB - genetics Receptor, trkC Receptors, Nerve Growth Factor - analysis Receptors, Nerve Growth Factor - genetics RNA, Messenger - analysis RNA, Messenger - genetics Sequence Homology, Amino Acid Species Specificity Vertebrates: nervous system and sense organs
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Zusammenfassung:	A truncated form of the human trkB gene has been cloned and sequenced. This gene is related to the trk family of tyrosine kinases, the products of which act as receptors for the neurotrophins. Of these, brain-derived neurotrophic factor and mammalian neurotrophin-4 are the known ligands for the TrkB receptor. Catalytic and non-catalytic (or truncated) forms of the trkB gene have been cloned for rat and mouse. In this study, using in situ hybridization, we describe the distribution of trkB messenger RNA in fetal and adult human brain.
ISSN:	0306-4522 1873-7544