Effects of Eicosapentaenoic Acid (20:5ω3) on Stress Reactivity in Rats
Abstract This study examined the effects of eicosapentaenoic acid (EPA) on cardiovascular responses to isolation stress in male rats. Group-reared rats, on a fat-free diet, were given olive oil (OL), or EPA in OL (1.47 x 10−7 mol/hr) via 8 week osmetic pumps, or a dummy pump (DUM), 2 weeks prior to...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1986-05, Vol.182 (1), p.127-131 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 182 |
| creator | Mills, D.E. Ward, R.P. |
| description | Abstract
This study examined the effects of eicosapentaenoic acid (EPA) on cardiovascular responses to isolation stress in male rats. Group-reared rats, on a fat-free diet, were given olive oil (OL), or EPA in OL (1.47 x 10−7 mol/hr) via 8 week osmetic pumps, or a dummy pump (DUM), 2 weeks prior to a 4 week isolation period. Blood pressure (BP) , heart rate, and body weight were monitored weekly and pressor responses to i.a. norepinephrine and angiotensin were assessed at the end of the study. BP increased during stress in all animals vs. pre-stress conditions, but was attenuated by EPA (p |
| doi_str_mv | 10.3181/00379727-182-1-RC1 |
| format | Article |
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This study examined the effects of eicosapentaenoic acid (EPA) on cardiovascular responses to isolation stress in male rats. Group-reared rats, on a fat-free diet, were given olive oil (OL), or EPA in OL (1.47 x 10−7 mol/hr) via 8 week osmetic pumps, or a dummy pump (DUM), 2 weeks prior to a 4 week isolation period. Blood pressure (BP) , heart rate, and body weight were monitored weekly and pressor responses to i.a. norepinephrine and angiotensin were assessed at the end of the study. BP increased during stress in all animals vs. pre-stress conditions, but was attenuated by EPA (p<0.001). Heart rate also increased during stress in all groups, but was greater in the EPA group (p<0.001). In contrast, body weight gain during stress was similar in DUM and EPA groups, but depressed by OL (p<0.001). Vascular response to norepinephrine was enhanced by EPA vs. DUM and OL, whereas the response to angiotensin was similar in EPA and DUM groups, but reduced by OL. These data suggest that EPA may attenuate cardiovascular responses to psychological Stress.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>EISSN: 1525-1373</identifier><identifier>DOI: 10.3181/00379727-182-1-RC1</identifier><identifier>PMID: 3008158</identifier><identifier>CODEN: PSEBAA</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Angiotensin II - pharmacology ; Animals ; Biological and medical sciences ; Blood Pressure - drug effects ; Body Weight - drug effects ; Eicosapentaenoic Acid - pharmacology ; Fundamental and applied biological sciences. Psychology ; Heart Rate - drug effects ; Male ; Norepinephrine - pharmacology ; Prostaglandins. Arachidonic acid metabolites ; Rats ; Rats, Inbred WKY ; Social Isolation ; Stress, Psychological - physiopathology ; Vertebrates: endocrinology</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1986-05, Vol.182 (1), p.127-131</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-436c11eeecbcd63283432de7b380bc8abc35f693d4212d9a1cdddb4d681d43fc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8188368$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3008158$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mills, D.E.</creatorcontrib><creatorcontrib>Ward, R.P.</creatorcontrib><title>Effects of Eicosapentaenoic Acid (20:5ω3) on Stress Reactivity in Rats</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Abstract
This study examined the effects of eicosapentaenoic acid (EPA) on cardiovascular responses to isolation stress in male rats. Group-reared rats, on a fat-free diet, were given olive oil (OL), or EPA in OL (1.47 x 10−7 mol/hr) via 8 week osmetic pumps, or a dummy pump (DUM), 2 weeks prior to a 4 week isolation period. Blood pressure (BP) , heart rate, and body weight were monitored weekly and pressor responses to i.a. norepinephrine and angiotensin were assessed at the end of the study. BP increased during stress in all animals vs. pre-stress conditions, but was attenuated by EPA (p<0.001). Heart rate also increased during stress in all groups, but was greater in the EPA group (p<0.001). In contrast, body weight gain during stress was similar in DUM and EPA groups, but depressed by OL (p<0.001). Vascular response to norepinephrine was enhanced by EPA vs. DUM and OL, whereas the response to angiotensin was similar in EPA and DUM groups, but reduced by OL. These data suggest that EPA may attenuate cardiovascular responses to psychological Stress.</description><subject>Angiotensin II - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Body Weight - drug effects</subject><subject>Eicosapentaenoic Acid - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart Rate - drug effects</subject><subject>Male</subject><subject>Norepinephrine - pharmacology</subject><subject>Prostaglandins. Arachidonic acid metabolites</subject><subject>Rats</subject><subject>Rats, Inbred WKY</subject><subject>Social Isolation</subject><subject>Stress, Psychological - physiopathology</subject><subject>Vertebrates: endocrinology</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><issn>1525-1373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1KAzEUhYMotf68gCBkIaKLsbm5M5mMOyn1BwSh6jpkbjISaWfqZCr0EXw6X8kprS5d3cX5zrnwMXYC4gpBw0gIzItc5glomUAyHcMOG0KGWYKqKHbZcA0ka2KfHcT4LgRkuVQDNkAhNGR6yO4mVeWpi7yp-CRQE-3C1531dROI31Bw_EKK6-z7Cy95U_PnrvUx8qm31IXP0K14qPnUdvGI7VV2Fv3x9h6y19vJy_g-eXy6exjfPCaUInZJiooAvPdUklMoNaYonc9L1KIkbUvCrFIFulSCdIUFcs6VqVMaXIoV4SE73-wu2uZj6WNn5iGSn81s7ZtlNLnK8wxV1oNyA1LbxNj6yizaMLftyoAwa3vm157p7Rkwvb2-dLpdX5Zz7_4qW119frbNbSQ7q1pbU4h_mAatUa2x0QaL9s2b92bZ1r2T_x7_AJ1QhIE</recordid><startdate>19860501</startdate><enddate>19860501</enddate><creator>Mills, D.E.</creator><creator>Ward, R.P.</creator><general>SAGE Publications</general><general>Blackwell Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19860501</creationdate><title>Effects of Eicosapentaenoic Acid (20:5ω3) on Stress Reactivity in Rats</title><author>Mills, D.E. ; Ward, R.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-436c11eeecbcd63283432de7b380bc8abc35f693d4212d9a1cdddb4d681d43fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Angiotensin II - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Body Weight - drug effects</topic><topic>Eicosapentaenoic Acid - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart Rate - drug effects</topic><topic>Male</topic><topic>Norepinephrine - pharmacology</topic><topic>Prostaglandins. Arachidonic acid metabolites</topic><topic>Rats</topic><topic>Rats, Inbred WKY</topic><topic>Social Isolation</topic><topic>Stress, Psychological - physiopathology</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mills, D.E.</creatorcontrib><creatorcontrib>Ward, R.P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mills, D.E.</au><au>Ward, R.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Eicosapentaenoic Acid (20:5ω3) on Stress Reactivity in Rats</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1986-05-01</date><risdate>1986</risdate><volume>182</volume><issue>1</issue><spage>127</spage><epage>131</epage><pages>127-131</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><eissn>1525-1373</eissn><coden>PSEBAA</coden><abstract>Abstract
This study examined the effects of eicosapentaenoic acid (EPA) on cardiovascular responses to isolation stress in male rats. Group-reared rats, on a fat-free diet, were given olive oil (OL), or EPA in OL (1.47 x 10−7 mol/hr) via 8 week osmetic pumps, or a dummy pump (DUM), 2 weeks prior to a 4 week isolation period. Blood pressure (BP) , heart rate, and body weight were monitored weekly and pressor responses to i.a. norepinephrine and angiotensin were assessed at the end of the study. BP increased during stress in all animals vs. pre-stress conditions, but was attenuated by EPA (p<0.001). Heart rate also increased during stress in all groups, but was greater in the EPA group (p<0.001). In contrast, body weight gain during stress was similar in DUM and EPA groups, but depressed by OL (p<0.001). Vascular response to norepinephrine was enhanced by EPA vs. DUM and OL, whereas the response to angiotensin was similar in EPA and DUM groups, but reduced by OL. These data suggest that EPA may attenuate cardiovascular responses to psychological Stress.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>3008158</pmid><doi>10.3181/00379727-182-1-RC1</doi><tpages>5</tpages></addata></record> |
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| ispartof | Experimental biology and medicine (Maywood, N.J.), 1986-05, Vol.182 (1), p.127-131 |
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| subjects | Angiotensin II - pharmacology Animals Biological and medical sciences Blood Pressure - drug effects Body Weight - drug effects Eicosapentaenoic Acid - pharmacology Fundamental and applied biological sciences. Psychology Heart Rate - drug effects Male Norepinephrine - pharmacology Prostaglandins. Arachidonic acid metabolites Rats Rats, Inbred WKY Social Isolation Stress, Psychological - physiopathology Vertebrates: endocrinology |
| title | Effects of Eicosapentaenoic Acid (20:5ω3) on Stress Reactivity in Rats |
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