Effects of Eicosapentaenoic Acid (20:5ω3) on Stress Reactivity in Rats

Abstract This study examined the effects of eicosapentaenoic acid (EPA) on cardiovascular responses to isolation stress in male rats. Group-reared rats, on a fat-free diet, were given olive oil (OL), or EPA in OL (1.47 x 10−7 mol/hr) via 8 week osmetic pumps, or a dummy pump (DUM), 2 weeks prior to...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 1986-05, Vol.182 (1), p.127-131
Hauptverfasser:	Mills, D.E., Ward, R.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - pharmacology Animals Biological and medical sciences Blood Pressure - drug effects Body Weight - drug effects Eicosapentaenoic Acid - pharmacology Fundamental and applied biological sciences. Psychology Heart Rate - drug effects Male Norepinephrine - pharmacology Prostaglandins. Arachidonic acid metabolites Rats Rats, Inbred WKY Social Isolation Stress, Psychological - physiopathology Vertebrates: endocrinology
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Zusammenfassung:	Abstract This study examined the effects of eicosapentaenoic acid (EPA) on cardiovascular responses to isolation stress in male rats. Group-reared rats, on a fat-free diet, were given olive oil (OL), or EPA in OL (1.47 x 10−7 mol/hr) via 8 week osmetic pumps, or a dummy pump (DUM), 2 weeks prior to a 4 week isolation period. Blood pressure (BP) , heart rate, and body weight were monitored weekly and pressor responses to i.a. norepinephrine and angiotensin were assessed at the end of the study. BP increased during stress in all animals vs. pre-stress conditions, but was attenuated by EPA (p
ISSN:	0037-9727 1535-3702 1535-3699 1525-1373
DOI:	10.3181/00379727-182-1-RC1