Gaba receptor binding site «induction» in rabbit retina after nipecotic acid treatment: changes during postnatal development

The development of the GABA system in the rabbit retina was studied. The number of high- and low-affinity GABA receptor binding sites increased in a sigmoidal manner, with the curve for the low-affinity sites lagging 2-3 days behind that for the high-affinity sites. The KD for both high- (17.5 nM) a...

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Veröffentlicht in:Neurochemical research 1986, Vol.11 (1), p.55-61
Hauptverfasser: MADTES, P. JR, BASHIR-ELAHI, R
Format: Artikel
Sprache:eng
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Zusammenfassung:The development of the GABA system in the rabbit retina was studied. The number of high- and low-affinity GABA receptor binding sites increased in a sigmoidal manner, with the curve for the low-affinity sites lagging 2-3 days behind that for the high-affinity sites. The KD for both high- (17.5 nM) and low-affinity (138.0 nM) sites remained constant during development. Treatment of isolated eyecups with the uptake blocker nipecotic acid resulted in an increase in the Bmax for high-affinity sites in developing tissue with the maximum sensitivity around eye opening; mature tissue exhibited a decrease in Bmax. In contrast, a gradual decrease in sensitivity to stimulation of the low-affinity sites occurred. These data indicate that the "trophic" action of GABA is limited to the time when the tissue is developing.
ISSN:0364-3190
1573-6903
DOI:10.1007/BF00965165