Reduced interferon-γ secretion in neonates and subsequent atopy

Summary Low interferon-γ (IFN-γ) secretion has been found in individuals with active atopic disease. Whether this is a cause or result of the disease process is uncertain. Cord blood IFN-γ secretion was examined in 35 neonates who were then prospectively followed up for 1 year for the development of atopic disease. Infants who developed either symptoms of atopic disease or a positive IgE-mediated skin prick test at 12 months of age produced significantly less IFN-γ at birth compared with those who did not (p = 0·005). This reduced secretion of IFN-γ at birth indicates that the defect in interferon secretion is a primary component of the atopic state rather than an effect of the disease process.