Effect of T3 modulation on pokeweed mitogen-induced T cell activation: evidence for an alternative pathway of T cell activation

Modulation of the T3 molecule on human T cells with monoclonal anti-T3 antibodies has been shown to result in the disappearance of the T3-Ti complex from the membrane and to preclude subsequent T cell activation by various mitogenic and antigenic stimuli. We have examined the effect of T3 modulation...

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Veröffentlicht in:	The Journal of immunology (1950) 1986-05, Vol.136 (9), p.3346-3350
Hauptverfasser:	Ceuppens, JL, Meurs, L, Baroja, ML, Van Wauwe, JP
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Antibodies, Monoclonal - physiology Antigens, Differentiation, T-Lymphocyte Antigens, Surface - immunology Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Immunological reactions in vitro Interleukin-2 - biosynthesis Interleukin-2 - metabolism Lymphoblastic transformation (stimulation by antigen, mitogen, mixed lymphocyte reactions) Lymphocyte Activation Male Mice Middle Aged Pokeweed Mitogens - pharmacology Receptors, Antigen, T-Cell - analysis Receptors, Immunologic - analysis Receptors, Interleukin-2 T-Lymphocytes - immunology T-Lymphocytes - metabolism Tumor Necrosis Factor Receptor Superfamily, Member 7
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