Translocation (2;3) in hematologic malignancies

Cytogenetic studies have revealed nonrandom involvement of some chromosomes in specific structural abnormalities in human neoplasias. In this report we present three patients with t(2;3) associated with hematologic malignancies, and review the pertinent literature. These findings lead us to regard t...

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Veröffentlicht in:	Cancer genetics and cytogenetics 1986-04, Vol.21 (4), p.335-342
Hauptverfasser:	Slavutsky, Irma, de Vinuesa, Mabel Labal, Larripa, Irene, Dupont, Juan, de Salum, Sonia Brieux
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adult Biological and medical sciences Chromosomes, Human, 1-3 Female Genetic Markers Hematologic and hematopoietic diseases Hodgkin Disease - genetics Humans Karyotyping Leukemia - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma - genetics Male Medical sciences Middle Aged Translocation, Genetic
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Zusammenfassung:	Cytogenetic studies have revealed nonrandom involvement of some chromosomes in specific structural abnormalities in human neoplasias. In this report we present three patients with t(2;3) associated with hematologic malignancies, and review the pertinent literature. These findings lead us to regard the region between 3q26 and 3q29 as implicated in chromosomal changes in these disorders, whereas, no vulnerable point has been observed in chromosome #2. We suggest that these translocations may activate genes on chromosome #3 related to these neoplasias.
ISSN:	0165-4608 1873-4456
DOI:	10.1016/0165-4608(86)90214-1