Effect of hypercapnia on fluid filtration rate during forward and reverse perfusion of isolated rabbit lungs
Fluid filtration rate (FFR) was measured under predominantly zone-three conditions in isolated rabbit lung perfused at constant flow. During forward and reverse perfusion, alveolar hypercapnia significantly increased mean pulmonary artery pressure but did not change FFR. We conclude that the pulmona...
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| Veröffentlicht in: | Critical care medicine 1986-04, Vol.14 (4), p.285-287 |
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| container_title | Critical care medicine |
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| creator | DE LEN, ROBERTO SÁNCHEZ BRAJKOVICH, IMPERIA ZABNER, JOSEPH MARTINEZ-RUIZ, RICARDO ANGELI, SIMN |
| description | Fluid filtration rate (FFR) was measured under predominantly zone-three conditions in isolated rabbit lung perfused at constant flow. During forward and reverse perfusion, alveolar hypercapnia significantly increased mean pulmonary artery pressure but did not change FFR. We conclude that the pulmonary vasoconstriction induced by alveolar hypercapnia occurs on both arterial and venular sides of the pulmonary circulation. |
| doi_str_mv | 10.1097/00003246-198604000-00007 |
| format | Article |
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During forward and reverse perfusion, alveolar hypercapnia significantly increased mean pulmonary artery pressure but did not change FFR. We conclude that the pulmonary vasoconstriction induced by alveolar hypercapnia occurs on both arterial and venular sides of the pulmonary circulation.</description><identifier>ISSN: 0090-3493</identifier><identifier>EISSN: 1530-0293</identifier><identifier>DOI: 10.1097/00003246-198604000-00007</identifier><identifier>PMID: 3082594</identifier><identifier>CODEN: CCMDC7</identifier><language>eng</language><publisher>Hagerstown, MD: Williams & Wilkins</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Biological and medical sciences ; Carbon Dioxide - blood ; Emergency and intensive respiratory care ; Hydrogen-Ion Concentration ; Hypercapnia - metabolism ; Hypercapnia - physiopathology ; Intensive care medicine ; Lung - metabolism ; Medical sciences ; Oxygen - blood ; Pulmonary Circulation ; Pulmonary Wedge Pressure ; Rabbits ; Space life sciences</subject><ispartof>Critical care medicine, 1986-04, Vol.14 (4), p.285-287</ispartof><rights>Williams & Wilkins 1986. 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During forward and reverse perfusion, alveolar hypercapnia significantly increased mean pulmonary artery pressure but did not change FFR. We conclude that the pulmonary vasoconstriction induced by alveolar hypercapnia occurs on both arterial and venular sides of the pulmonary circulation.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carbon Dioxide - blood</subject><subject>Emergency and intensive respiratory care</subject><subject>Hydrogen-Ion Concentration</subject><subject>Hypercapnia - metabolism</subject><subject>Hypercapnia - physiopathology</subject><subject>Intensive care medicine</subject><subject>Lung - metabolism</subject><subject>Medical sciences</subject><subject>Oxygen - blood</subject><subject>Pulmonary Circulation</subject><subject>Pulmonary Wedge Pressure</subject><subject>Rabbits</subject><subject>Space life sciences</subject><issn>0090-3493</issn><issn>1530-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU2PFCEQhonRrLOrP8GEg_HWK3TR0BzNZv1INvGiZ8JHsYMy3SN0O9l_L-OMc5NLpd73qSK8EEI5u-VMq_esHeiF7LgeJROt646SekY2fIDW9Bqekw1jmnUgNLwk17X-YIyLQcEVuQI29oMWG5LvY0S_0DnS7dMei7f7KVk6TzTmNQUaU16KXVITWkEa1pKmRxrncrAlUDsFWvA3loq0Tce1Hsm2LNU5N7651rm00LxOj_UVeRFtrvj6XG_I94_33-4-dw9fP325-_DQeRiF6kAqEKN3UXAcrAYxcBGid-isG1wAHZhzOMTAEDlXshcKYNRN4VJIQLgh705792X-tWJdzC5VjznbCee1GiWVkOPQN3A8gb7MtRaMZl_SzpYnw5k5Bm3-BW0uQf-VVBt9c75jdTsMl8Fzss1_e_Zt9TbHYief6gUbpeDtsQ0TJ-ww56XF-DOvByxmizYvW_O_b4Y_Zm-Wmw</recordid><startdate>198604</startdate><enddate>198604</enddate><creator>DE LEN, ROBERTO SÁNCHEZ</creator><creator>BRAJKOVICH, IMPERIA</creator><creator>ZABNER, JOSEPH</creator><creator>MARTINEZ-RUIZ, RICARDO</creator><creator>ANGELI, SIMN</creator><general>Williams & Wilkins</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198604</creationdate><title>Effect of hypercapnia on fluid filtration rate during forward and reverse perfusion of isolated rabbit lungs</title><author>DE LEN, ROBERTO SÁNCHEZ ; BRAJKOVICH, IMPERIA ; ZABNER, JOSEPH ; MARTINEZ-RUIZ, RICARDO ; ANGELI, SIMN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3847-367348cbf41e5a934514dfcbebab5bd39d0bbe5fd0ee11762473389e5f16463e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carbon Dioxide - blood</topic><topic>Emergency and intensive respiratory care</topic><topic>Hydrogen-Ion Concentration</topic><topic>Hypercapnia - metabolism</topic><topic>Hypercapnia - physiopathology</topic><topic>Intensive care medicine</topic><topic>Lung - metabolism</topic><topic>Medical sciences</topic><topic>Oxygen - blood</topic><topic>Pulmonary Circulation</topic><topic>Pulmonary Wedge Pressure</topic><topic>Rabbits</topic><topic>Space life sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DE LEN, ROBERTO SÁNCHEZ</creatorcontrib><creatorcontrib>BRAJKOVICH, IMPERIA</creatorcontrib><creatorcontrib>ZABNER, JOSEPH</creatorcontrib><creatorcontrib>MARTINEZ-RUIZ, RICARDO</creatorcontrib><creatorcontrib>ANGELI, SIMN</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DE LEN, ROBERTO SÁNCHEZ</au><au>BRAJKOVICH, IMPERIA</au><au>ZABNER, JOSEPH</au><au>MARTINEZ-RUIZ, RICARDO</au><au>ANGELI, SIMN</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of hypercapnia on fluid filtration rate during forward and reverse perfusion of isolated rabbit lungs</atitle><jtitle>Critical care medicine</jtitle><addtitle>Crit Care Med</addtitle><date>1986-04</date><risdate>1986</risdate><volume>14</volume><issue>4</issue><spage>285</spage><epage>287</epage><pages>285-287</pages><issn>0090-3493</issn><eissn>1530-0293</eissn><coden>CCMDC7</coden><abstract>Fluid filtration rate (FFR) was measured under predominantly zone-three conditions in isolated rabbit lung perfused at constant flow. During forward and reverse perfusion, alveolar hypercapnia significantly increased mean pulmonary artery pressure but did not change FFR. We conclude that the pulmonary vasoconstriction induced by alveolar hypercapnia occurs on both arterial and venular sides of the pulmonary circulation.</abstract><cop>Hagerstown, MD</cop><pub>Williams & Wilkins</pub><pmid>3082594</pmid><doi>10.1097/00003246-198604000-00007</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0090-3493 |
| ispartof | Critical care medicine, 1986-04, Vol.14 (4), p.285-287 |
| issn | 0090-3493 1530-0293 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76746852 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Carbon Dioxide - blood Emergency and intensive respiratory care Hydrogen-Ion Concentration Hypercapnia - metabolism Hypercapnia - physiopathology Intensive care medicine Lung - metabolism Medical sciences Oxygen - blood Pulmonary Circulation Pulmonary Wedge Pressure Rabbits Space life sciences |
| title | Effect of hypercapnia on fluid filtration rate during forward and reverse perfusion of isolated rabbit lungs |
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