A 6-Hydroxydopamine-Induced Selective Parkinsonian Rat Model: Further Biochemical and Behavioral Characterization

A 6-Hydroxydopamine-Induced Selective Parkinsonian Rat Model: Further Biochemical and Behavioral Characterization

The main focus of the present study was to define the rotational response of 6-hydroxydopamine-lesioned rats to dopaminergic agonists to separate the partially lesioned rats from those having complete substantia nigra (SN) and ventral tegmental area (VTA) lesions. Animals were challenged by amphetam...

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Veröffentlicht in:Experimental neurology 1994-04, Vol.126 (2), p.159-167
Hauptverfasser: Thomas, John, Wang, Jin, Takubo, Hideki, Sheng, Jengen, de Jesus, Samuel, Bankiewicz, Krzysztof S.
Format: Artikel
Sprache:eng
Schlagworte:
Amphetamine - pharmacology
Animals
Biological and medical sciences
Brain - metabolism
Brain - pathology
Carbidopa - pharmacology
Caudate Nucleus - metabolism
Corpus Striatum - enzymology
Corpus Striatum - pathology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dopamine - metabolism
Drug Combinations
Functional Laterality
Immunohistochemistry
Levodopa - pharmacology
Male
Medical sciences
Mesencephalon - enzymology
Mesencephalon - pathology
Models, Neurological
Motor Activity - drug effects
Motor Activity - physiology
Neurology
Nucleus Accumbens - metabolism
Oxidopamine
Parkinson Disease, Secondary - metabolism
Parkinson Disease, Secondary - pathology
Parkinson Disease, Secondary - physiopathology
Rats
Rats, Sprague-Dawley
Rotation
Tyrosine 3-Monooxygenase - analysis
Tyrosine 3-Monooxygenase - metabolism
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Beschreibung
Zusammenfassung:The main focus of the present study was to define the rotational response of 6-hydroxydopamine-lesioned rats to dopaminergic agonists to separate the partially lesioned rats from those having complete substantia nigra (SN) and ventral tegmental area (VTA) lesions. Animals were challenged by amphetamine and L-DOPA for 10 consecutive weeks. There was a correlation between rotational behavior and extent of midbrain cell loss. Rats with complete SN and
ISSN:0014-4886
1090-2430
DOI:10.1006/exnr.1994.1054