Protein tyrosine kinases and TNFα secretion in human monocytes

The role of protein tyrosine kinases (PTK) in TNFα secretion by human monocytes was investigated in this report. We showed that an immunomodulator such as Nocardia lysozyme digest (NLD) and a particulate agonist, zymosan, stimulated an increase in tyrosine phosphorylation of several endogenous subst...

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Veröffentlicht in:	International journal of immunopharmacology 1994-05, Vol.16 (5), p.407-412
Hauptverfasser:	Lepidi, H., Ciubotariu, R., Bongrand, P., Capo, C., Barot-Ciorbaru, R., Mege, J.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Humans monocytes Monocytes - metabolism Muramidase - pharmacology Nocardia - immunology Nocardia opaca Phosphorylation protein tyrosine kinase Protein-Tyrosine Kinases - physiology TNFα Tumor Necrosis Factor-alpha - metabolism Tyrosine - metabolism zymosan Zymosan - pharmacology
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Zusammenfassung:	The role of protein tyrosine kinases (PTK) in TNFα secretion by human monocytes was investigated in this report. We showed that an immunomodulator such as Nocardia lysozyme digest (NLD) and a particulate agonist, zymosan, stimulated an increase in tyrosine phosphorylation of several endogenous substrates including 53–56 kDa protein which was the predominant phosphoprotein. In addition, NLD and zymosan induced TNFα secretion which was impaired by a PTK inhibitor, tyrphostin. We suggest that a cascade of kinases including PTK is involved in NLD and zymosan signalling.
ISSN:	0192-0561 1879-3495
DOI:	10.1016/0192-0561(94)90029-9