GLYCOTHIOHEXIDE α, A NOVEL ANTIBIOTIC PRODUCED BY "Sebekia" sp., LL-14E605: III. STRUCTURAL ELUCIDATION

GLYCOTHIOHEXIDE α, A NOVEL ANTIBIOTIC PRODUCED BY "Sebekia" sp., LL-14E605: III. STRUCTURAL ELUCIDATION

The chemical structure of a novel thiopeptide antibiotic, glycothiohexide α (1), isolated from the fermentation broth of a "Sebekia" species was determined based on extensive 2D NMR studies, as well as, IR, UV, and mass spectral data. The chemical structure of glycothiohexide α is closely...

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Veröffentlicht in:Journal of antibiotics 1994/08/25, Vol.47(8), pp.901-908
Hauptverfasser: NORTHCOTE, P. T., SIEGEL, M., BORDERS, D. B., LEE, M. D.
Format: Artikel
Sprache:eng
Schlagworte:
Anti-Bacterial Agents - chemistry
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Electron Probe Microanalysis
Glutamates - chemistry
Glycosides - chemistry
Indoles - chemistry
Magnetic Resonance Spectroscopy - methods
Mass Spectrometry
Medical sciences
Molecular Structure
Peptides
Pharmacology. Drug treatments
Spectrophotometry, Infrared - methods
Spectrum Analysis - methods
Threonine - analogs & derivatives
Threonine - chemistry
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Zusammenfassung:The chemical structure of a novel thiopeptide antibiotic, glycothiohexide α (1), isolated from the fermentation broth of a "Sebekia" species was determined based on extensive 2D NMR studies, as well as, IR, UV, and mass spectral data. The chemical structure of glycothiohexide α is closely related to nosiheptide (3) and antibiotic S-54832A.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.47.901