The dynamic regulation of integrin adhesiveness

The integrins are a family of transmembrane heterodimeric adhesion molecules that play important roles in wound healing, immune system function and organ development. Recent studies indicate that adhesion of integrins to their ligands is not constitutive but is dynamically regulated by intracellular...

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Veröffentlicht in:Current Biology 1994-06, Vol.4 (6), p.506-517
Hauptverfasser: Diamond, Michael S., Springer, Timothy A.
Format: Artikel
Sprache:eng
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Zusammenfassung:The integrins are a family of transmembrane heterodimeric adhesion molecules that play important roles in wound healing, immune system function and organ development. Recent studies indicate that adhesion of integrins to their ligands is not constitutive but is dynamically regulated by intracellular signal transduction pathways.
ISSN:0960-9822
1879-0445
DOI:10.1016/S0960-9822(00)00111-1