Antipicornavirus activity of substituted phenoxybenzenes and phenoxypyridines

Phenoxybenzenes and phenoxypyridines were prepared and tested for the effect of substituents on antipicornavirus activity. The most active compound, 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile (8), demonstrated broad-spectrum antipicornavirus activity. Compound 8 and several analogues each given ora...

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Veröffentlicht in:	Journal of medicinal chemistry 1986-03, Vol.29 (3), p.427-433
Hauptverfasser:	Markley, Lowell D, Tong, Yulan C, Dulworth, Jacqueline K, Steward, David L, Goralski, Christopher T, Johnston, Howard, Wood, Steven G, Vinogradoff, Anna P, Bargar, Thomas M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - chemical synthesis Benzene Derivatives - chemical synthesis Benzene Derivatives - pharmacology Biological and medical sciences Cell Division - drug effects Cell Survival - drug effects Coxsackievirus Infections - drug therapy Cytopathogenic Effect, Viral - drug effects Enterovirus - drug effects General pharmacology HeLa Cells Humans Medical sciences Mice Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Picornaviridae - drug effects Pyridines - chemical synthesis Pyridines - pharmacology Rhinovirus - drug effects Structure-Activity Relationship
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Zusammenfassung:	Phenoxybenzenes and phenoxypyridines were prepared and tested for the effect of substituents on antipicornavirus activity. The most active compound, 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile (8), demonstrated broad-spectrum antipicornavirus activity. Compound 8 and several analogues each given orally prior to and during infection protected mice against an otherwise lethal challenge with coxsackievirus A21.
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm00153a020