MICROBIAL PRODUCTS: VIII. AZINOTHRICIN, A NOVEL HEXADEPSIPEPTIDE ANTIBIOTIC

Azinothricin was isolated from the culture filtrate of Streptomyces sp. X-14950 in crystalline form. It represents a new type of hexadepsipeptide antibiotic as it contains a 19-membered cyclodepsipeptide ring composed of six unusual amino acids and bearing a novel C21 side chain. Azinothricin was id...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of antibiotics 1986, Vol.39(1), pp.17-25
Hauptverfasser:	MAEHR, HUBERT, LIU, CHAO-MIN, PALLERONI, NORBERTO J., SMALLHEER, JOANNE, TODARO, LOUIS, WILLIAMS, THOMAS H., BLOUNT, JOHN F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - analysis Antibiotics Biological and medical sciences Biotechnology Fermentation Fundamental and applied biological sciences. Psychology General pharmacology Gram-Positive Bacteria - drug effects Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Magnetic Resonance Spectroscopy Mass Spectrometry Medical sciences Microbial Sensitivity Tests Microscopy, Electron Models, Molecular Peptides Peptides, Cyclic - analysis Peptides, Cyclic - pharmacology Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Production of active biomolecules Spectrophotometry, Infrared Streptomyces - analysis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Azinothricin was isolated from the culture filtrate of Streptomyces sp. X-14950 in crystalline form. It represents a new type of hexadepsipeptide antibiotic as it contains a 19-membered cyclodepsipeptide ring composed of six unusual amino acids and bearing a novel C21 side chain. Azinothricin was identified as [(3S, 4S, 7R(S), 10S, 17R, 20S, 23R)[2S(2'R, 5'S, 6'S)3S*]]-α-ethyl - 6 -(3-ethyl-1, 5-dimethyl-4-oxo-1, 5-heptadienyl)- N-(1, 8, 14, 15, 18, 21, 27-heptaaza-21-hydroxy- 7-(1-hydroxyethyl) -2, 6, 9, 16, 19, 22-hexaoxo 4-isopropyl-20-(methoxymethyl)-17, 18-dimethyl-5-oxatricyclo[21.4.0.010, 15]heptacosan-3-yl)tetrahydro-α, 2-dihydroxy-5-methyl-2H-pyran-2-acetamide and is primarily active against Gram-positive microorganisms.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.39.17