Localization of the OTF3 Gene within the Human MHC Class I Region by Physical and Meiotic Mapping

OTF3 (octamer transcription factor 3) is a transcription factor containing a POU-specific domain and a homeodomain that could play a role in early development. In situ hybridization and pairwise linkage analysis showed that OTF3 gene maps close to the human MHC (major histocompatibility complex). In...

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Veröffentlicht in:	Genomics (San Diego, Calif.) Calif.), 1994-05, Vol.21 (1), p.241-243
Hauptverfasser:	Crouau-Roy, Brigitte, Amadou, Claire, Bouissou, Cathy, Clayton, John, Vernet, Corine, Ribouchon, Marie-Thérèse, Pontarotti, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Biological and medical sciences Chromosome Mapping - methods Chromosomes, Artificial, Yeast Classical genetics, quantitative genetics, hybrids Crossing Over, Genetic DNA-Binding Proteins - genetics Embryonic and Fetal Development - genetics Fundamental and applied biological sciences. Psychology Genes Genetics of eukaryotes. Biological and molecular evolution Haplotypes - genetics Human Humans In Situ Hybridization Major Histocompatibility Complex Meiosis Octamer Transcription Factor-3 Transcription Factors - genetics
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Beschreibung
Zusammenfassung:	OTF3 (octamer transcription factor 3) is a transcription factor containing a POU-specific domain and a homeodomain that could play a role in early development. In situ hybridization and pairwise linkage analysis showed that OTF3 gene maps close to the human MHC (major histocompatibility complex). In this paper, we define its localization within the MHC, around 100 kb telomeric to HLA-C, using a combination of physical and genetic analyses.
ISSN:	0888-7543 1089-8646
DOI:	10.1006/geno.1994.1249