Biosynthetic pathway for a new series of gangliosides, GT1aα and GQ1bα

A new class of gangliosides, GT1aα and GQ1bα, were initially identified as cholinergic neuron-specific antigens in bovine brain. These gangliosides have in common α2–6 NeuAc linked to the GalNAc residue in the gangliotetraose core structure. In this study, we have determined the biosynthetic pathway...

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Veröffentlicht in:	FEBS letters 1994-09, Vol.351 (2), p.291-294
Hauptverfasser:	Irie, Fumitoshi, Jwa Hidari, Kazuya I.-P., Tai, Tadashi, Li, Yu-Teh, Seyama, Yousuke, Hirabayashi, Yoshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbohydrate Sequence Cattle Cholinergic Fibers - chemistry Cholinergic neuron-specific antigen Female Gal, galactose GalNAc, N-acetylgalactosamine Ganglioside Ganglioside biosynthesis Gangliosides - analysis Gangliosides - biosynthesis Glc, glucose Golgi Apparatus - metabolism HPTLC, high performance thin layer chromatography Liver - enzymology Molecular Sequence Data NeuAc, N-acetylneuraminic acid Rats Sialyltransferase Sialyltransferases - metabolism Subcellular Fractions - metabolism The nomenclature used for gangliosides is based on the system of Svennerhorm and Hirabayashi et al. [9,24]. Cer, ceramide TLC, thin layer chromatography
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