Biosynthetic pathway for a new series of gangliosides, GT1aα and GQ1bα
A new class of gangliosides, GT1aα and GQ1bα, were initially identified as cholinergic neuron-specific antigens in bovine brain. These gangliosides have in common α2–6 NeuAc linked to the GalNAc residue in the gangliotetraose core structure. In this study, we have determined the biosynthetic pathway...
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| Veröffentlicht in: | FEBS letters 1994-09, Vol.351 (2), p.291-294 |
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| creator | Irie, Fumitoshi Jwa Hidari, Kazuya I.-P. Tai, Tadashi Li, Yu-Teh Seyama, Yousuke Hirabayashi, Yoshio |
| description | A new class of gangliosides, GT1aα and GQ1bα, were initially identified as cholinergic neuron-specific antigens in bovine brain. These gangliosides have in common α2–6 NeuAc linked to the GalNAc residue in the gangliotetraose core structure. In this study, we have determined the biosynthetic pathways of GT1aα and GQ1bα using rat liver Golgi fraction. The results showed that GT1aα and GQ1bα were synthesized from GD1a and GT1b, respectively, by the action of a GalNAc α2–6 sialyltransferase. It was also demonstrated that these two gangliosides were found to exist as extremely minor components in rat liver. |
| doi_str_mv | 10.1016/0014-5793(94)00883-3 |
| format | Article |
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These gangliosides have in common α2–6 NeuAc linked to the GalNAc residue in the gangliotetraose core structure. In this study, we have determined the biosynthetic pathways of GT1aα and GQ1bα using rat liver Golgi fraction. The results showed that GT1aα and GQ1bα were synthesized from GD1a and GT1b, respectively, by the action of a GalNAc α2–6 sialyltransferase. It was also demonstrated that these two gangliosides were found to exist as extremely minor components in rat liver.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/0014-5793(94)00883-3</identifier><identifier>PMID: 8082783</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Animals ; Carbohydrate Sequence ; Cattle ; Cholinergic Fibers - chemistry ; Cholinergic neuron-specific antigen ; Female ; Gal, galactose ; GalNAc, N-acetylgalactosamine ; Ganglioside ; Ganglioside biosynthesis ; Gangliosides - analysis ; Gangliosides - biosynthesis ; Glc, glucose ; Golgi Apparatus - metabolism ; HPTLC, high performance thin layer chromatography ; Liver - enzymology ; Molecular Sequence Data ; NeuAc, N-acetylneuraminic acid ; Rats ; Sialyltransferase ; Sialyltransferases - metabolism ; Subcellular Fractions - metabolism ; The nomenclature used for gangliosides is based on the system of Svennerhorm and Hirabayashi et al. [9,24]. Cer, ceramide ; TLC, thin layer chromatography</subject><ispartof>FEBS letters, 1994-09, Vol.351 (2), p.291-294</ispartof><rights>1994</rights><rights>FEBS Letters 351 (1994) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4203-cf8693031cfe92ae2b2addc3b41a20c205dbb9f99bf32775f970e5eac6ac36fd3</citedby><cites>FETCH-LOGICAL-c4203-cf8693031cfe92ae2b2addc3b41a20c205dbb9f99bf32775f970e5eac6ac36fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0014579394008833$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8082783$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Irie, Fumitoshi</creatorcontrib><creatorcontrib>Jwa Hidari, Kazuya I.-P.</creatorcontrib><creatorcontrib>Tai, Tadashi</creatorcontrib><creatorcontrib>Li, Yu-Teh</creatorcontrib><creatorcontrib>Seyama, Yousuke</creatorcontrib><creatorcontrib>Hirabayashi, Yoshio</creatorcontrib><title>Biosynthetic pathway for a new series of gangliosides, GT1aα and GQ1bα</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>A new class of gangliosides, GT1aα and GQ1bα, were initially identified as cholinergic neuron-specific antigens in bovine brain. These gangliosides have in common α2–6 NeuAc linked to the GalNAc residue in the gangliotetraose core structure. In this study, we have determined the biosynthetic pathways of GT1aα and GQ1bα using rat liver Golgi fraction. The results showed that GT1aα and GQ1bα were synthesized from GD1a and GT1b, respectively, by the action of a GalNAc α2–6 sialyltransferase. It was also demonstrated that these two gangliosides were found to exist as extremely minor components in rat liver.</description><subject>Animals</subject><subject>Carbohydrate Sequence</subject><subject>Cattle</subject><subject>Cholinergic Fibers - chemistry</subject><subject>Cholinergic neuron-specific antigen</subject><subject>Female</subject><subject>Gal, galactose</subject><subject>GalNAc, N-acetylgalactosamine</subject><subject>Ganglioside</subject><subject>Ganglioside biosynthesis</subject><subject>Gangliosides - analysis</subject><subject>Gangliosides - biosynthesis</subject><subject>Glc, glucose</subject><subject>Golgi Apparatus - metabolism</subject><subject>HPTLC, high performance thin layer chromatography</subject><subject>Liver - enzymology</subject><subject>Molecular Sequence Data</subject><subject>NeuAc, N-acetylneuraminic acid</subject><subject>Rats</subject><subject>Sialyltransferase</subject><subject>Sialyltransferases - metabolism</subject><subject>Subcellular Fractions - metabolism</subject><subject>The nomenclature used for gangliosides is based on the system of Svennerhorm and Hirabayashi et al. [9,24]. Cer, ceramide</subject><subject>TLC, thin layer chromatography</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtKAzEUhoMoWi9voJCVKDiay1ySjaBiW0EQQdchk5xoZDpTk6mlj9UX8ZmcaYtLcZXk_P_5CB9Cx5RcUkLzK0JommSF5GcyPSdECJ7wLTSgouguaS620eC3sof2Y_wg3VtQuYt2BRGsEHyAxre-iYu6fYfWGzzV7ftcL7BrAta4hjmOEDxE3Dj8puu3qit7C_ECj16o_l5iXVs8eqbl9_IQ7ThdRTjanAfodXj_cjdOHp9GD3c3j4lJGeGJcSKXnHBqHEimgZVMW2t4mVLNiGEks2UpnZSl46woMicLAhlok2vDc2f5ATpdc6eh-ZxBbNXERwNVpWtoZlEVeUFZnuVdMV0XTWhiDODUNPiJDgtFieoFqt6O6u0omaqVQMW7tZMNf1ZOwP4ubYx1-XCdz30Fi38x1fD-lvVBP5fpatqDrtcg6Gx9eQgqGg-1AesDmFbZxv_90x8kgpNv</recordid><startdate>19940905</startdate><enddate>19940905</enddate><creator>Irie, Fumitoshi</creator><creator>Jwa Hidari, Kazuya I.-P.</creator><creator>Tai, Tadashi</creator><creator>Li, Yu-Teh</creator><creator>Seyama, Yousuke</creator><creator>Hirabayashi, Yoshio</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940905</creationdate><title>Biosynthetic pathway for a new series of gangliosides, GT1aα and GQ1bα</title><author>Irie, Fumitoshi ; Jwa Hidari, Kazuya I.-P. ; Tai, Tadashi ; Li, Yu-Teh ; Seyama, Yousuke ; Hirabayashi, Yoshio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4203-cf8693031cfe92ae2b2addc3b41a20c205dbb9f99bf32775f970e5eac6ac36fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Carbohydrate Sequence</topic><topic>Cattle</topic><topic>Cholinergic Fibers - chemistry</topic><topic>Cholinergic neuron-specific antigen</topic><topic>Female</topic><topic>Gal, galactose</topic><topic>GalNAc, N-acetylgalactosamine</topic><topic>Ganglioside</topic><topic>Ganglioside biosynthesis</topic><topic>Gangliosides - analysis</topic><topic>Gangliosides - biosynthesis</topic><topic>Glc, glucose</topic><topic>Golgi Apparatus - metabolism</topic><topic>HPTLC, high performance thin layer chromatography</topic><topic>Liver - enzymology</topic><topic>Molecular Sequence Data</topic><topic>NeuAc, N-acetylneuraminic acid</topic><topic>Rats</topic><topic>Sialyltransferase</topic><topic>Sialyltransferases - metabolism</topic><topic>Subcellular Fractions - metabolism</topic><topic>The nomenclature used for gangliosides is based on the system of Svennerhorm and Hirabayashi et al. [9,24]. Cer, ceramide</topic><topic>TLC, thin layer chromatography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Irie, Fumitoshi</creatorcontrib><creatorcontrib>Jwa Hidari, Kazuya I.-P.</creatorcontrib><creatorcontrib>Tai, Tadashi</creatorcontrib><creatorcontrib>Li, Yu-Teh</creatorcontrib><creatorcontrib>Seyama, Yousuke</creatorcontrib><creatorcontrib>Hirabayashi, Yoshio</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Irie, Fumitoshi</au><au>Jwa Hidari, Kazuya I.-P.</au><au>Tai, Tadashi</au><au>Li, Yu-Teh</au><au>Seyama, Yousuke</au><au>Hirabayashi, Yoshio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biosynthetic pathway for a new series of gangliosides, GT1aα and GQ1bα</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1994-09-05</date><risdate>1994</risdate><volume>351</volume><issue>2</issue><spage>291</spage><epage>294</epage><pages>291-294</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>A new class of gangliosides, GT1aα and GQ1bα, were initially identified as cholinergic neuron-specific antigens in bovine brain. These gangliosides have in common α2–6 NeuAc linked to the GalNAc residue in the gangliotetraose core structure. In this study, we have determined the biosynthetic pathways of GT1aα and GQ1bα using rat liver Golgi fraction. The results showed that GT1aα and GQ1bα were synthesized from GD1a and GT1b, respectively, by the action of a GalNAc α2–6 sialyltransferase. It was also demonstrated that these two gangliosides were found to exist as extremely minor components in rat liver.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>8082783</pmid><doi>10.1016/0014-5793(94)00883-3</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | FEBS letters, 1994-09, Vol.351 (2), p.291-294 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Carbohydrate Sequence Cattle Cholinergic Fibers - chemistry Cholinergic neuron-specific antigen Female Gal, galactose GalNAc, N-acetylgalactosamine Ganglioside Ganglioside biosynthesis Gangliosides - analysis Gangliosides - biosynthesis Glc, glucose Golgi Apparatus - metabolism HPTLC, high performance thin layer chromatography Liver - enzymology Molecular Sequence Data NeuAc, N-acetylneuraminic acid Rats Sialyltransferase Sialyltransferases - metabolism Subcellular Fractions - metabolism The nomenclature used for gangliosides is based on the system of Svennerhorm and Hirabayashi et al. [9,24]. Cer, ceramide TLC, thin layer chromatography |
| title | Biosynthetic pathway for a new series of gangliosides, GT1aα and GQ1bα |
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