Evidence of Abnormalities in Corticosteroid Secretion Leading to Volume-Dependent Hypertension in Milan Rats
We examined corticosteroid secretory patterns and their relation to altered salt and water metabolism Milan hypertensive and normotensive rats. Hypertensive rats had significantly higher blood pressures, exchangeable sodium (hypertensive, 41.2±03 mmol·kg; normotensive, 38.4±0.03 mmol·kg, P
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| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 1994-10, Vol.24 (4), p.512-515 |
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| container_title | Hypertension (Dallas, Tex. 1979) |
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| creator | Fraser, Robert Ancil, Aidan K Brown, William B Ingram, Mary C Holloway, Christine D Henderson, Ian W Kenyon, Christopher J |
| description | We examined corticosteroid secretory patterns and their relation to altered salt and water metabolism Milan hypertensive and normotensive rats. Hypertensive rats had significantly higher blood pressures, exchangeable sodium (hypertensive, 41.2±03 mmol·kg; normotensive, 38.4±0.03 mmol·kg, P |
| doi_str_mv | 10.1161/01.HYP.24.4.512 |
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Hypertensive rats had significantly higher blood pressures, exchangeable sodium (hypertensive, 41.2±03 mmol·kg; normotensive, 38.4±0.03 mmol·kg, P<.001), plasma volume (hypertensive, 5.39±0.12 mL·100g; normotensive, 4.84±0.10 mL·100 g P<.001), and plasma concentrations of atrial natriuretic pep-tide (hypertensive, 38.8±4.0 pg-mL, normotensive, 22.4±3.1 pg-mL, P<.02). These features coincide with those of mineralocorticoid-induced hypertension. Adrenal ve-nous secretory rates (picomoles per minute) of corticosterone (hypertensive, 1696±202; normotensive, 873±139),18-hydroxy-corticosterone (hypertensive, 49.7±8.3; normotensive, 25.7±3.3), and aldosterone (hypertensive, 1.16±0.17; nor-motensive, 0.52±0.08) were higher in the hypertensive than the normotensive strain, but that of 11-deoxycorticosterone (DOC) (hypertensive, 94.4±14.9; normotensive, 114.3±33.9) was similar in the two strains. The corticosterone-DOC, 18-hydroxycorticosterone- DOC, and aldosterone-DOC ratios were higher in the hypertensive than the normotensive strain (P<.02), but the 18-hydroxycorticosterone-corticosterone and aldosterone-18-hydroxycorticosterone ratios were not. These results indicate increased activity of the “late” aldosterone biosynthetic pathway in the hypertensive compared with the normotensive strain caused by an increased conversion rate of DOC to corticosterone. The comparison of corticosterone secretion between the two strains indicates that 11β-hydroxy-lase rather than aldosterone synthase activity is more active in the hypertensive than the normotensive rats.</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/01.HYP.24.4.512</identifier><identifier>PMID: 8088920</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>18-Hydroxycorticosterone - metabolism ; Adrenal Glands - abnormalities ; Aldosterone - metabolism ; Animals ; Atrial Natriuretic Factor - blood ; Blood Pressure ; Body Water - metabolism ; Corticosterone - biosynthesis ; Corticosterone - metabolism ; Desoxycorticosterone - biosynthesis ; Desoxycorticosterone - metabolism ; Hypertension - etiology ; Hypertension - metabolism ; Male ; Plasma Volume ; Rats ; Sodium - metabolism ; Species Specificity</subject><ispartof>Hypertension (Dallas, Tex. 1979), 1994-10, Vol.24 (4), p.512-515</ispartof><rights>1994 American Heart Association, Inc.</rights><rights>Copyright American Heart Association, Inc. Oct 1994</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4054-6e3b9b284aeef7376bd98be248c4b43f64d9f0ee6bb5a5b90dfe9d028735f2ea3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8088920$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fraser, Robert</creatorcontrib><creatorcontrib>Ancil, Aidan K</creatorcontrib><creatorcontrib>Brown, William B</creatorcontrib><creatorcontrib>Ingram, Mary C</creatorcontrib><creatorcontrib>Holloway, Christine D</creatorcontrib><creatorcontrib>Henderson, Ian W</creatorcontrib><creatorcontrib>Kenyon, Christopher J</creatorcontrib><title>Evidence of Abnormalities in Corticosteroid Secretion Leading to Volume-Dependent Hypertension in Milan Rats</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>We examined corticosteroid secretory patterns and their relation to altered salt and water metabolism Milan hypertensive and normotensive rats. Hypertensive rats had significantly higher blood pressures, exchangeable sodium (hypertensive, 41.2±03 mmol·kg; normotensive, 38.4±0.03 mmol·kg, P<.001), plasma volume (hypertensive, 5.39±0.12 mL·100g; normotensive, 4.84±0.10 mL·100 g P<.001), and plasma concentrations of atrial natriuretic pep-tide (hypertensive, 38.8±4.0 pg-mL, normotensive, 22.4±3.1 pg-mL, P<.02). These features coincide with those of mineralocorticoid-induced hypertension. Adrenal ve-nous secretory rates (picomoles per minute) of corticosterone (hypertensive, 1696±202; normotensive, 873±139),18-hydroxy-corticosterone (hypertensive, 49.7±8.3; normotensive, 25.7±3.3), and aldosterone (hypertensive, 1.16±0.17; nor-motensive, 0.52±0.08) were higher in the hypertensive than the normotensive strain, but that of 11-deoxycorticosterone (DOC) (hypertensive, 94.4±14.9; normotensive, 114.3±33.9) was similar in the two strains. The corticosterone-DOC, 18-hydroxycorticosterone- DOC, and aldosterone-DOC ratios were higher in the hypertensive than the normotensive strain (P<.02), but the 18-hydroxycorticosterone-corticosterone and aldosterone-18-hydroxycorticosterone ratios were not. These results indicate increased activity of the “late” aldosterone biosynthetic pathway in the hypertensive compared with the normotensive strain caused by an increased conversion rate of DOC to corticosterone. The comparison of corticosterone secretion between the two strains indicates that 11β-hydroxy-lase rather than aldosterone synthase activity is more active in the hypertensive than the normotensive rats.</description><subject>18-Hydroxycorticosterone - metabolism</subject><subject>Adrenal Glands - abnormalities</subject><subject>Aldosterone - metabolism</subject><subject>Animals</subject><subject>Atrial Natriuretic Factor - blood</subject><subject>Blood Pressure</subject><subject>Body Water - metabolism</subject><subject>Corticosterone - biosynthesis</subject><subject>Corticosterone - metabolism</subject><subject>Desoxycorticosterone - biosynthesis</subject><subject>Desoxycorticosterone - metabolism</subject><subject>Hypertension - etiology</subject><subject>Hypertension - metabolism</subject><subject>Male</subject><subject>Plasma Volume</subject><subject>Rats</subject><subject>Sodium - metabolism</subject><subject>Species Specificity</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUFv1DAQhS1EVZaWMyckiwO3pLYzceJjtZQu0lYgKAhOlp1MqEsSL7bTqv8er3bFgbmMRvPN09M8Ql5zVnIu-QXj5ebn51JACWXNxTOy4rWAAmpZPScrxhUUivMfL8jLGO8Z4wDQnJLTlrWtEmxFxqsH1-PcIfUDvbSzD5MZXXIYqZvp2ofkOh8TBu96-hW7gMn5mW7R9G7-RZOn3_24TFi8xx3OWSnRzdMOQ8I57sEscuNGM9MvJsVzcjKYMeKrYz8j3z5c3a43xfbT9cf15bbogNVQSKyssqIFgzg0VSNtr1qLAtoOLFSDhF4NDFFaW5vaKtYPqHom2qaqB4GmOiPvDrq74P8sGJOeXOxwzD7QL1E3suFcCZHBt_-B934Jc_amBauFlKJiGbo4QF3wMQYc9C64yYQnzZneh6AZ1zkELUCDziHkizdH2cVO2P_jj1_PezjsH_2YXxt_j8sjBn2HZkx3muUCIduCKwV8PxVsn1z1Fw-skzo</recordid><startdate>199410</startdate><enddate>199410</enddate><creator>Fraser, Robert</creator><creator>Ancil, Aidan K</creator><creator>Brown, William B</creator><creator>Ingram, Mary C</creator><creator>Holloway, Christine D</creator><creator>Henderson, Ian W</creator><creator>Kenyon, Christopher J</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>199410</creationdate><title>Evidence of Abnormalities in Corticosteroid Secretion Leading to Volume-Dependent Hypertension in Milan Rats</title><author>Fraser, Robert ; Ancil, Aidan K ; Brown, William B ; Ingram, Mary C ; Holloway, Christine D ; Henderson, Ian W ; Kenyon, Christopher J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4054-6e3b9b284aeef7376bd98be248c4b43f64d9f0ee6bb5a5b90dfe9d028735f2ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>18-Hydroxycorticosterone - metabolism</topic><topic>Adrenal Glands - abnormalities</topic><topic>Aldosterone - metabolism</topic><topic>Animals</topic><topic>Atrial Natriuretic Factor - blood</topic><topic>Blood Pressure</topic><topic>Body Water - metabolism</topic><topic>Corticosterone - biosynthesis</topic><topic>Corticosterone - metabolism</topic><topic>Desoxycorticosterone - biosynthesis</topic><topic>Desoxycorticosterone - metabolism</topic><topic>Hypertension - etiology</topic><topic>Hypertension - metabolism</topic><topic>Male</topic><topic>Plasma Volume</topic><topic>Rats</topic><topic>Sodium - metabolism</topic><topic>Species Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fraser, Robert</creatorcontrib><creatorcontrib>Ancil, Aidan K</creatorcontrib><creatorcontrib>Brown, William B</creatorcontrib><creatorcontrib>Ingram, Mary C</creatorcontrib><creatorcontrib>Holloway, Christine D</creatorcontrib><creatorcontrib>Henderson, Ian W</creatorcontrib><creatorcontrib>Kenyon, Christopher J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fraser, Robert</au><au>Ancil, Aidan K</au><au>Brown, William B</au><au>Ingram, Mary C</au><au>Holloway, Christine D</au><au>Henderson, Ian W</au><au>Kenyon, Christopher J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence of Abnormalities in Corticosteroid Secretion Leading to Volume-Dependent Hypertension in Milan Rats</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>1994-10</date><risdate>1994</risdate><volume>24</volume><issue>4</issue><spage>512</spage><epage>515</epage><pages>512-515</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract>We examined corticosteroid secretory patterns and their relation to altered salt and water metabolism Milan hypertensive and normotensive rats. Hypertensive rats had significantly higher blood pressures, exchangeable sodium (hypertensive, 41.2±03 mmol·kg; normotensive, 38.4±0.03 mmol·kg, P<.001), plasma volume (hypertensive, 5.39±0.12 mL·100g; normotensive, 4.84±0.10 mL·100 g P<.001), and plasma concentrations of atrial natriuretic pep-tide (hypertensive, 38.8±4.0 pg-mL, normotensive, 22.4±3.1 pg-mL, P<.02). These features coincide with those of mineralocorticoid-induced hypertension. Adrenal ve-nous secretory rates (picomoles per minute) of corticosterone (hypertensive, 1696±202; normotensive, 873±139),18-hydroxy-corticosterone (hypertensive, 49.7±8.3; normotensive, 25.7±3.3), and aldosterone (hypertensive, 1.16±0.17; nor-motensive, 0.52±0.08) were higher in the hypertensive than the normotensive strain, but that of 11-deoxycorticosterone (DOC) (hypertensive, 94.4±14.9; normotensive, 114.3±33.9) was similar in the two strains. The corticosterone-DOC, 18-hydroxycorticosterone- DOC, and aldosterone-DOC ratios were higher in the hypertensive than the normotensive strain (P<.02), but the 18-hydroxycorticosterone-corticosterone and aldosterone-18-hydroxycorticosterone ratios were not. These results indicate increased activity of the “late” aldosterone biosynthetic pathway in the hypertensive compared with the normotensive strain caused by an increased conversion rate of DOC to corticosterone. The comparison of corticosterone secretion between the two strains indicates that 11β-hydroxy-lase rather than aldosterone synthase activity is more active in the hypertensive than the normotensive rats.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>8088920</pmid><doi>10.1161/01.HYP.24.4.512</doi><tpages>4</tpages></addata></record> |
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| ispartof | Hypertension (Dallas, Tex. 1979), 1994-10, Vol.24 (4), p.512-515 |
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| source | Journals@Ovid Ovid Autoload; MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 18-Hydroxycorticosterone - metabolism Adrenal Glands - abnormalities Aldosterone - metabolism Animals Atrial Natriuretic Factor - blood Blood Pressure Body Water - metabolism Corticosterone - biosynthesis Corticosterone - metabolism Desoxycorticosterone - biosynthesis Desoxycorticosterone - metabolism Hypertension - etiology Hypertension - metabolism Male Plasma Volume Rats Sodium - metabolism Species Specificity |
| title | Evidence of Abnormalities in Corticosteroid Secretion Leading to Volume-Dependent Hypertension in Milan Rats |
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