Evidence of Abnormalities in Corticosteroid Secretion Leading to Volume-Dependent Hypertension in Milan Rats

We examined corticosteroid secretory patterns and their relation to altered salt and water metabolism Milan hypertensive and normotensive rats. Hypertensive rats had significantly higher blood pressures, exchangeable sodium (hypertensive, 41.2±03 mmol·kg; normotensive, 38.4±0.03 mmol·kg, P

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 1994-10, Vol.24 (4), p.512-515
Hauptverfasser:	Fraser, Robert, Ancil, Aidan K, Brown, William B, Ingram, Mary C, Holloway, Christine D, Henderson, Ian W, Kenyon, Christopher J
Format:	Artikel
Sprache:	eng
Schlagworte:	18-Hydroxycorticosterone - metabolism Adrenal Glands - abnormalities Aldosterone - metabolism Animals Atrial Natriuretic Factor - blood Blood Pressure Body Water - metabolism Corticosterone - biosynthesis Corticosterone - metabolism Desoxycorticosterone - biosynthesis Desoxycorticosterone - metabolism Hypertension - etiology Hypertension - metabolism Male Plasma Volume Rats Sodium - metabolism Species Specificity
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Beschreibung
Zusammenfassung:	We examined corticosteroid secretory patterns and their relation to altered salt and water metabolism Milan hypertensive and normotensive rats. Hypertensive rats had significantly higher blood pressures, exchangeable sodium (hypertensive, 41.2±03 mmol·kg; normotensive, 38.4±0.03 mmol·kg, P
ISSN:	0194-911X 1524-4563
DOI:	10.1161/01.HYP.24.4.512