The NMDA antagonist MK-801 blocks light effect on melatonin receptor density in rat suprachiasmatic nuclei

In pinealectomized rats, melatonin receptor density in the suprachiasmatic nuclei was recently shown to be strongly decreased during the dark period. Furthermore, a one-hour long light pulse is able to reverse this dark-induced decrease. We demonstrate here that this effect of a light-pulse during n...

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Veröffentlicht in:	Neuroscience letters 1994-04, Vol.171 (1), p.24-26
Hauptverfasser:	Gauer, F., Masson-Pévet, M., Pévet, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chronobiology Dizocilpine Maleate - pharmacology Fundamental and applied biological sciences. Psychology Light Light pulse Male Melatonin Melatonin - pharmacokinetics Melatonin receptor MK-801 NMDA receptor Pineal Gland - physiology Pinealectomy Protein Binding Rats Rats, Wistar Receptors, Cell Surface - drug effects Receptors, Cell Surface - radiation effects Receptors, Melatonin Suprachiasmatic nucleus Suprachiasmatic Nucleus - drug effects Suprachiasmatic Nucleus - metabolism Suprachiasmatic Nucleus - radiation effects Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Zusammenfassung:	In pinealectomized rats, melatonin receptor density in the suprachiasmatic nuclei was recently shown to be strongly decreased during the dark period. Furthermore, a one-hour long light pulse is able to reverse this dark-induced decrease. We demonstrate here that this effect of a light-pulse during night time is blocked by prior application of the NMDA receptor antagonist MK-801. These results show that the light effect on melatonin receptor density in the SCN is mediated by activation of NMDA-type receptors.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(94)90595-9