Heteroduplex stabilities in highly repetitive DNA: An hypothesis for the polymorphism of Plasmodium parasite antigenic response

Codon repeats encountered in DNA sequences may formally lead to several double-stranded structures of similar stabilities. This is observed in the highly repetitive sequences of some Plasmodium antigens (S-antigen, CS proteins). It is postulated that gene recombination may occur via various heterodu...

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Veröffentlicht in:	FEBS letters 1986-03, Vol.197 (1), p.5-8
1. Verfasser:	Dodin, Guy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Protozoan - genetics Biochemistry. Physiology. Immunology. Molecular biology Biological and medical sciences Biological Evolution DNA - genetics Fundamental and applied biological sciences. Psychology Malaria Antigenic polymorphism (Plasmodium) Repetitive sequence Models, Biological Nucleic Acid Heteroduplexes Plasmodium Plasmodium - genetics Plasmodium - immunology Plasmodium falciparum - genetics Plasmodium falciparum - immunology Polymorphism, Genetic Protozoa Recombination, Genetic Repetitive Sequences, Nucleic Acid
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Codon repeats encountered in DNA sequences may formally lead to several double-stranded structures of similar stabilities. This is observed in the highly repetitive sequences of some Plasmodium antigens (S-antigen, CS proteins). It is postulated that gene recombination may occur via various heteroduplex molecules thus leading to antigenic polymorphism of Plasmodium parasites.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(86)80286-1