Platelet-activating factor mobilises intracellular calcium in vascular smooth muscle cells

The effect of platelet-activating factor (PAF) on polyphosphoinositide metabolism and 45Ca 2+ efflux was examined in a vascular smooth muscle cell line (A 7r 5). PAF stimulated a rapid but transient production of inositol trisphosphate and inositol bisphosphate which, in the presence of lithium, res...

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Veröffentlicht in:	FEBS letters 1986-03, Vol.197 (1), p.13-16
Hauptverfasser:	Doyle, Valerie M., Creba, Judith A., Rüegg, Urs T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Aorta Biological and medical sciences Ca 2+ Inositol phosphate Platelet-activating factor (Rat smooth muscle) Ca2+ Inositol phosphate Platelet-activating factor (Rat smooth muscle) Calcium - metabolism Cell Line Fundamental and applied biological sciences. Psychology Inositol - metabolism Inositol Phosphates - biosynthesis Kinetics Lithium - pharmacology Muscle, Smooth, Vascular - metabolism Platelet Activating Factor - physiology Protein hormones. Growth factors. Cytokines Proteins Rats Sugar Phosphates - biosynthesis
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Zusammenfassung:	The effect of platelet-activating factor (PAF) on polyphosphoinositide metabolism and 45Ca 2+ efflux was examined in a vascular smooth muscle cell line (A 7r 5). PAF stimulated a rapid but transient production of inositol trisphosphate and inositol bisphosphate which, in the presence of lithium, resulted in an accumulation of inositol monophosphate. In addition, PAF induced a rapid efflux of 45Ca 2+ from preloaded cells, an effect which was concentration-dependent. These data suggest that PAF mobilises intracellular Ca 2+ via the production of inositol trisphosphate.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(86)80288-5