Zinc and paired-pulse potentiation in the hippocampus

Zinc was added to the perfusate of rat hippocampal slices to determine the effect on the potentiation of evoked responses in subfield CA3 following paired-pulse stimulation of mossy fibres. Paired-pulse potentiation across a range of interpulse intervals and currents was significantly depressed by 5...

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Veröffentlicht in:	Brain research 1986-01, Vol.363 (1), p.152-155
Hauptverfasser:	Khulusi, Samim S., Brown, Malcolm W., Wright, D. Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Central nervous system Electrophysiology Evoked Potentials - drug effects Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - metabolism hippocampal formation Hippocampus - drug effects In Vitro Techniques Male potentiation Rats Rats, Inbred Strains Stimulation, Chemical Synaptic Transmission - drug effects Vertebrates: nervous system and sense organs zinc Zinc - pharmacology
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Zusammenfassung:	Zinc was added to the perfusate of rat hippocampal slices to determine the effect on the potentiation of evoked responses in subfield CA3 following paired-pulse stimulation of mossy fibres. Paired-pulse potentiation across a range of interpulse intervals and currents was significantly depressed by 50 and 500 μM zinc chloride. Additionally but only at the higher concentration, the amplitude of the first evoked potential was significantly increased. These results provide further evidence of a role for zinc in hippocampal neurotransmission.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(86)90669-4