Spatial structures in mitochondrial suspension induced by cation efflux

The formation of spatial structures in a thin unstirred layer of a mitochondrial suspension has been studied. It is shown that the structure formation depends on the state of the ion-transporting systems of mitochondria and that pattern development coincides with the activation of cation efflux from...

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Veröffentlicht in:FEBS letters 1986-01, Vol.195 (1), p.339-343
Hauptverfasser: Holmuhamedov, E.L., Evtodienko, Yu.V.
Format: Artikel
Sprache:eng
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Zusammenfassung:The formation of spatial structures in a thin unstirred layer of a mitochondrial suspension has been studied. It is shown that the structure formation depends on the state of the ion-transporting systems of mitochondria and that pattern development coincides with the activation of cation efflux from preloaded mitochondria. Spatial structure formation is an energy-dependent process and is suppressed by respiratory chain inhibitors. Patterning is also inhibited by EGTA, EDTA and ruthenium red, reflecting the requirement for divalent cation translocation in mitochondria for the studied phenomenon.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(86)80189-2