Cardiopulmonary Effects of a Single Oral Dose of Almitrine at Rest and on Exercise in Patients with Hypoxic Chronic Airflow Obstruction

Almitrine, a new triazine derivative, was studied in a double-blind, randomized, parallel study in 16 patients with hypoxic chronic airflow obstruction (eight almitrine and eight placebo). At rest, compared to placebo, a 3 mg/kg single dose of almitrine given orally significantly increased the parti...

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Veröffentlicht in:	Chest 1986-02, Vol.89 (2), p.174-179
Hauptverfasser:	Simonneau, Gérald, Meignan, Michel, Denjean, André, Raffestin, Bernadette, Harf, Alain, Prost, Jean-François
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Aged Almitrine Biological and medical sciences Central Nervous System Stimulants - administration & dosage Central Nervous System Stimulants - therapeutic use Clinical Trials as Topic Double-Blind Method Hemodynamics - drug effects Humans Lung Diseases, Obstructive - drug therapy Medical sciences Middle Aged Pharmacology. Drug treatments Physical Exertion Piperazines - administration & dosage Piperazines - therapeutic use Pulmonary Gas Exchange - drug effects Random Allocation Respiration - drug effects Respiratory system Space life sciences
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Zusammenfassung:	Almitrine, a new triazine derivative, was studied in a double-blind, randomized, parallel study in 16 patients with hypoxic chronic airflow obstruction (eight almitrine and eight placebo). At rest, compared to placebo, a 3 mg/kg single dose of almitrine given orally significantly increased the partial pressure of oxygen (mean increase: +12.0± SEM 2.1 mm Hg, p
ISSN:	0012-3692 1931-3543
DOI:	10.1378/chest.89.2.174