Effects of stress and ebiratide (Hoe-427) on free-choice ethanol consumption: Comparison of lewis and Sprague-Dawley rats
The effects of immobilization stress, isolation stress and administration of Hoe-427 on free-choice consumption of ethanol by Lewis and Sprague-Dawley rats were studied. The animals were offered two-bottle choice consumption of 0.2% saccharin and 10% ethanol/0.2% saccharin, then exposed to 4 days of...
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Veröffentlicht in: | Life sciences (1973) 1994, Vol.55 (11), p.873-878 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The effects of immobilization stress, isolation stress and administration of Hoe-427 on free-choice consumption of ethanol by Lewis and Sprague-Dawley rats were studied. The animals were offered two-bottle choice consumption of 0.2% saccharin and 10% ethanol/0.2% saccharin, then exposed to 4 days of immobilization stress or isolation stress on an irregular, unpredictable schedule or 4 days of i.p. doses of Hoe-427 at 1800 hours. Both stresses resulted in significant decreases in ethanol consumption during the stress period. Hoe-427 produced a significant decrease in ethanol consumption, in a dose-dependent manner. Saccharin consumption was not significantly affected by any of the treatments. The ability to correlate the Lewis and Sprague-Dawley rat response further aids in supporting the role of the adrenocorticotropic peptide in the development of ethanol consumption. |
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ISSN: | 0024-3205 1879-0631 |
DOI: | 10.1016/0024-3205(94)90043-4 |