Brain Glucose Metabolism in Alzheimer’s Disease

In vitro determination of brain glucose metabolism in the temporal cortex from patients with Alzheimer’s disease showed a marked decrease when compared with nonde-mented, age-matched control subjects. Additional determinations on normal human temporal cortex obtained at autopsy demonstrated an age-d...

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Veröffentlicht in:	The American journal of the medical sciences 1994-09, Vol.308 (3), p.141-144
Hauptverfasser:	Swerdlow, Russell, Marcus, David L., Landman, Jaime, Kooby, David, Frey, William, Freedman, Michael L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alzheimer Disease - metabolism Alzheimer’s disease Biological and medical sciences Brain - metabolism Brain glucose metabolism Dementia Geriatrics Glucose - metabolism Humans Medical sciences Middle Aged Positron emission tomography Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Temporal cortex Temporal Lobe - metabolism Tomography, Emission-Computed
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Beschreibung
Zusammenfassung:	In vitro determination of brain glucose metabolism in the temporal cortex from patients with Alzheimer’s disease showed a marked decrease when compared with nonde-mented, age-matched control subjects. Additional determinations on normal human temporal cortex obtained at autopsy demonstrated an age-dependent decline in the rate of glucose use. These data provide an in vitro correlate for positron emission tomography studies that suggest decreased brain glucose use in Alzheimer’s disease.
ISSN:	0002-9629 1538-2990
DOI:	10.1097/00000441-199409000-00003