On the interaction of the aromatic part of dopaminergic agonists with the receptor
Structure-activity analysis of some selected, structurally diverse dopaminergic agonists that interact presumably with the D-2 receptor subtype was based on matching the minima of molecular electrostatic potential. Congruent superimpositions may indicate that the aromatic or heterocyclic portions of...
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| Veröffentlicht in: | Journal of medicinal chemistry 1994-09, Vol.37 (18), p.2851-2855 |
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| container_end_page | 2855 |
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| container_issue | 18 |
| container_start_page | 2851 |
| container_title | Journal of medicinal chemistry |
| container_volume | 37 |
| creator | Kocjan, Darko |
| description | Structure-activity analysis of some selected, structurally diverse dopaminergic agonists that interact presumably with the D-2 receptor subtype was based on matching the minima of molecular electrostatic potential. Congruent superimpositions may indicate that the aromatic or heterocyclic portions of the structure interact with the receptor via pi- or lone pair electron density. The interaction of the aromatic or heterocyclic XH (X = O, N) group or substituent as a hydrogen bond proton donor seems not to be essential for binding and activating the dopamine receptor. |
| doi_str_mv | 10.1021/jm00044a005 |
| format | Article |
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The interaction of the aromatic or heterocyclic XH (X = O, N) group or substituent as a hydrogen bond proton donor seems not to be essential for binding and activating the dopamine receptor.</description><subject>Biological and medical sciences</subject><subject>Catecholaminergic system</subject><subject>Dopamine Agents - chemistry</subject><subject>Dopamine Agents - metabolism</subject><subject>Electrochemistry</subject><subject>Ergolines - metabolism</subject><subject>Medical sciences</subject><subject>Models, Molecular</subject><subject>Molecular Conformation</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Pharmacology. 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| identifier | ISSN: 0022-2623 |
| ispartof | Journal of medicinal chemistry, 1994-09, Vol.37 (18), p.2851-2855 |
| issn | 0022-2623 1520-4804 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76676368 |
| source | MEDLINE; American Chemical Society Publications |
| subjects | Biological and medical sciences Catecholaminergic system Dopamine Agents - chemistry Dopamine Agents - metabolism Electrochemistry Ergolines - metabolism Medical sciences Models, Molecular Molecular Conformation Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Quantum Theory Receptors, Dopamine - metabolism Structure-Activity Relationship |
| title | On the interaction of the aromatic part of dopaminergic agonists with the receptor |
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