On the interaction of the aromatic part of dopaminergic agonists with the receptor

Structure-activity analysis of some selected, structurally diverse dopaminergic agonists that interact presumably with the D-2 receptor subtype was based on matching the minima of molecular electrostatic potential. Congruent superimpositions may indicate that the aromatic or heterocyclic portions of the structure interact with the receptor via pi- or lone pair electron density. The interaction of the aromatic or heterocyclic XH (X = O, N) group or substituent as a hydrogen bond proton donor seems not to be essential for binding and activating the dopamine receptor.