Effect of Phencyclidine on the Metabolism of Individual Brain Proteins
: The effect of phencyclidine on the metabolism of a selected number of rat brain proteins was determined using two‐dimensional gel electrophoresis and quantitative fluorography. When rats were injected with phencyclidine, modulation of individual protein metabolism occurred in the pituitary and cor...
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| Veröffentlicht in: | Journal of neurochemistry 1986-02, Vol.46 (2), p.470-474 |
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| container_end_page | 474 |
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| container_issue | 2 |
| container_start_page | 470 |
| container_title | Journal of neurochemistry |
| container_volume | 46 |
| creator | Koul, Omanand March, James E. Sarma, Raqhupathy Griffiths, Cynthia Deutsch, Dale G. |
| description | : The effect of phencyclidine on the metabolism of a selected number of rat brain proteins was determined using two‐dimensional gel electrophoresis and quantitative fluorography. When rats were injected with phencyclidine, modulation of individual protein metabolism occurred in the pituitary and cortex. That is, a few proteins showed increased and others decreased incorporation of [35S]methionine, whereas total protein metabolism was unaltered. In contrast, in vitro treatment of brain tissue with phencyclidine inhibited incorporation of ra‐diolabel into all proteins by — 50%, as shown by quantitative fluorography of individual proteins. |
| doi_str_mv | 10.1111/j.1471-4159.1986.tb12991.x |
| format | Article |
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When rats were injected with phencyclidine, modulation of individual protein metabolism occurred in the pituitary and cortex. That is, a few proteins showed increased and others decreased incorporation of [35S]methionine, whereas total protein metabolism was unaltered. 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When rats were injected with phencyclidine, modulation of individual protein metabolism occurred in the pituitary and cortex. That is, a few proteins showed increased and others decreased incorporation of [35S]methionine, whereas total protein metabolism was unaltered. In contrast, in vitro treatment of brain tissue with phencyclidine inhibited incorporation of ra‐diolabel into all proteins by — 50%, as shown by quantitative fluorography of individual proteins.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Brain proteins</subject><subject>Drug addictions</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>Fluorometry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methionine - metabolism</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Phencyclidine</subject><subject>Phencyclidine - pharmacology</subject><subject>Pituitary Gland - drug effects</subject><subject>Pituitary Gland - metabolism</subject><subject>Protein metabolism</subject><subject>Rats</subject><subject>Toxicology</subject><issn>0022-3042</issn><issn>1471-4159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkFFLwzAQx4Moc04_glBEfGtN0ixpfBB0bDqZugd9Dml6YRldq02r27e3ZWXv3stx_H93CT-ErgiOSFu364gwQUJGxjIiMuFRnRIqJYm2R2h4iI7REGNKwxgzeorOvF9jTDjjZIAGsWQkJmKIZlNrwdRBaYPlCgqzM7nLXAFBWQT1CoJXqHVa5s5vOmReZO7HZY3Og8dKuyJYVmUNrvDn6MTq3MNF30foczb9mDyHi_en-eRhEZpYJji0CTOpJMYmmmMheEYgtZxJTTHjGU2TzMKYtgPY1IIWTGsQqRZYAEuosfEI3ezvflXldwO-VhvnDeS5LqBsvBKci5iycQve7UFTld5XYNVX5Ta62imCVSdRrVVnSnWmVCdR9RLVtl2-7F9p0g1kh9XeWptf97n2Rue20oVx_oAJKTBN4ha732O_LofdPz6gXt4mTOD4DxSEjsE</recordid><startdate>198602</startdate><enddate>198602</enddate><creator>Koul, Omanand</creator><creator>March, James E.</creator><creator>Sarma, Raqhupathy</creator><creator>Griffiths, Cynthia</creator><creator>Deutsch, Dale G.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198602</creationdate><title>Effect of Phencyclidine on the Metabolism of Individual Brain Proteins</title><author>Koul, Omanand ; March, James E. ; Sarma, Raqhupathy ; Griffiths, Cynthia ; Deutsch, Dale G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3980-f84cb91cf8a60776d1ebf649a2046d2b8dfe52204efbfea74aae7ba707e482cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Brain proteins</topic><topic>Drug addictions</topic><topic>Electrophoresis, Polyacrylamide Gel</topic><topic>Fluorometry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methionine - metabolism</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Phencyclidine</topic><topic>Phencyclidine - pharmacology</topic><topic>Pituitary Gland - drug effects</topic><topic>Pituitary Gland - metabolism</topic><topic>Protein metabolism</topic><topic>Rats</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koul, Omanand</creatorcontrib><creatorcontrib>March, James E.</creatorcontrib><creatorcontrib>Sarma, Raqhupathy</creatorcontrib><creatorcontrib>Griffiths, Cynthia</creatorcontrib><creatorcontrib>Deutsch, Dale G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koul, Omanand</au><au>March, James E.</au><au>Sarma, Raqhupathy</au><au>Griffiths, Cynthia</au><au>Deutsch, Dale G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Phencyclidine on the Metabolism of Individual Brain Proteins</atitle><jtitle>Journal of neurochemistry</jtitle><addtitle>J Neurochem</addtitle><date>1986-02</date><risdate>1986</risdate><volume>46</volume><issue>2</issue><spage>470</spage><epage>474</epage><pages>470-474</pages><issn>0022-3042</issn><eissn>1471-4159</eissn><coden>JONRA9</coden><abstract>: The effect of phencyclidine on the metabolism of a selected number of rat brain proteins was determined using two‐dimensional gel electrophoresis and quantitative fluorography. 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| fulltext | fulltext |
| identifier | ISSN: 0022-3042 |
| ispartof | Journal of neurochemistry, 1986-02, Vol.46 (2), p.470-474 |
| issn | 0022-3042 1471-4159 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Biological and medical sciences Brain - drug effects Brain - metabolism Brain proteins Drug addictions Electrophoresis, Polyacrylamide Gel Fluorometry Male Medical sciences Methionine - metabolism Nerve Tissue Proteins - metabolism Phencyclidine Phencyclidine - pharmacology Pituitary Gland - drug effects Pituitary Gland - metabolism Protein metabolism Rats Toxicology |
| title | Effect of Phencyclidine on the Metabolism of Individual Brain Proteins |
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