Novel Antitumor Sesquiterpenoids in Achillea millefolium

Three new antitumor sesquiterpenoids, achimillic acids A, B and C, were isolated as methyl esters from Achillea millefolium and their structures were determined spectroscopically. The compounds were found to be active against mouse P-388 leukemia cells in vivo.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical & pharmaceutical bulletin 1994/05/15, Vol.42(5), pp.1096-1100
Hauptverfasser:	TOZYO, Takehiko, YOSHIMURA, Yohko, SAKURAI, Kensuke, UCHIDA, Naomi, TAKEDA, Yukihiro, NAKAI, Hiroshi, ISHII, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Achillea millefolium achimillic acid Animals Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology antitumor activity Biological and medical sciences Cell Division - drug effects Compositae Crystallography, X-Ray General pharmacology Leukemia P388 - pathology Magnetic Resonance Spectroscopy Male Medical sciences Methylation Mice P-388 leukemia Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemistry Plant Extracts - pharmacology Plants, Medicinal - chemistry Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology sesquiterpenoid Tumor Cells, Cultured
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Beschreibung
Zusammenfassung:	Three new antitumor sesquiterpenoids, achimillic acids A, B and C, were isolated as methyl esters from Achillea millefolium and their structures were determined spectroscopically. The compounds were found to be active against mouse P-388 leukemia cells in vivo.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.42.1096