Interference by Parvolex with Chloride Estimation by the Ag/AgCl Method

We demonstrate significant interference by Parvolex (acetylcysteine) with the Ag/AgCl method for chloride estimation. A study of four patients who had taken a paracetamol overdose and been treated with Parvolex implied this interference, and an in vitro study confirmed it. The interference was shown...

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Veröffentlicht in:	Annals of clinical biochemistry 1994-03, Vol.31 (2), p.181-183
Hauptverfasser:	Bishell, G P, Lewis, H, Rooke, R A, Davies, H R
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood Glucose - analysis Chlorides - blood Cystine - analogs & derivatives Cystine - pharmacology Electrolytes - blood Humans In Vitro Techniques Investigative techniques, diagnostic techniques (general aspects) Medical sciences Miscellaneous. Technology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Silver Compounds Urea - blood
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Beschreibung
Zusammenfassung:	We demonstrate significant interference by Parvolex (acetylcysteine) with the Ag/AgCl method for chloride estimation. A study of four patients who had taken a paracetamol overdose and been treated with Parvolex implied this interference, and an in vitro study confirmed it. The interference was shown to decline upon storage of the serum at a similar rate in both the patient and in vitro studies. Suggested mechanisms for these phenomena are given.
ISSN:	0004-5632 1758-1001
DOI:	10.1177/000456329403100212