HLA-DQA1 and -DQB1 gene haplotypes in familial cardiomyopathy

HLA-DQA1 and -DQB1 gene haplotypes in familial cardiomyopathy

Observations in familial dilated cardiomyopathy suggest a role for the human leukocyte antigen (HLA)-DQB1 gene in the susceptibility to cardiac disease. Both HLA-DQB1 and HLA-DQA1 haplotypes are associated with disease expression and autoantibody production.

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Bibliographische Detailangaben
Veröffentlicht in:The American journal of cardiology 1994-09, Vol.74 (5), p.510-512
Hauptverfasser: Limas, Catherine, Limas, Constantinos J., Boudoulas, Harisios, Bair, Robert, Sparks, Libby, Graber, Harry, Wooley, Charles F.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Autoimmunity
Base Sequence
Biological and medical sciences
Cardiology. Vascular system
Cardiomyopathy, Dilated - genetics
Cardiomyopathy, Dilated - immunology
Cardiovascular disease
Female
Genes
Haplotypes
Heart
HLA-DQ alpha-Chains
HLA-DQ Antigens - genetics
HLA-DQ beta-Chains
Humans
Male
Medical research
Medical sciences
Middle Aged
Molecular Sequence Data
Myocarditis. Cardiomyopathies
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Beschreibung
Zusammenfassung:Observations in familial dilated cardiomyopathy suggest a role for the human leukocyte antigen (HLA)-DQB1 gene in the susceptibility to cardiac disease. Both HLA-DQB1 and HLA-DQA1 haplotypes are associated with disease expression and autoantibody production.
ISSN:0002-9149
1879-1913
DOI:10.1016/0002-9149(94)90918-0