Otitis Media with Effusion Following Inoculation of Endotoxin of Haemophilus influenzae Type B

The etiology and pathogenesis of otitis media with effusion (OME) as yet remains to be elucidated. OME was considered a sterile condition until recent reports of isolation of bacteria from the effusion of OME. The incidence of Haemophilus influenzae is high chronic OME cases. Consequently working on the postulation that endotoxin from H. influenzae may play some role in the development of OME, the endotoxin was extracted and inoculated into the tympanic bullae of guinea pigs.