Prevalence of serum antibodies against the p53 tumor suppressor gene protein in various cancers

Prevalence of serum antibodies against the p53 tumor suppressor gene protein in various cancers

We have developed 2 new quantitative methods for measuring anti‐p53 antibodies in human serum. Using these methods we analyzed 1,392 sera from patients with various malignancies and 230 sera from individuals without malignancy. Highest prevalence of anti‐p53 antibodies was associated with ovarian an...

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Veröffentlicht in:International journal of cancer 1994-08, Vol.58 (4), p.480-487
Hauptverfasser: Angelopoulou, Katerina, Diamandis, Eleftherios P., Sutherland, Donald J. A., Kellen, John A., Bunting, Peter S.
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Antibodies, Neoplasm - blood
Biological and medical sciences
Blotting, Western
Brain Neoplasms - immunology
Carcinoembryonic Antigen - analysis
Colonic Neoplasms - immunology
Female
Host-tumor relations. Immunology. Biological markers
Humans
Medical sciences
Methods
Middle Aged
Neoplasms - immunology
Ovarian Neoplasms - immunology
Prognosis
Tumor Suppressor Protein p53 - immunology
Tumors
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Zusammenfassung:We have developed 2 new quantitative methods for measuring anti‐p53 antibodies in human serum. Using these methods we analyzed 1,392 sera from patients with various malignancies and 230 sera from individuals without malignancy. Highest prevalence of anti‐p53 antibodies was associated with ovarian and colon cancers (15%), followed by lung (8%) and breast (5%) cancers. Prevalence in other malignancies was lower (
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.2910580404