The Importance of G1m and 2 Allotypes for the IgG2 Antibody Levels and Avidity Against Pneumococcal Polysaccharide Type 1 Within Mono‐ and Dizygotic Twin‐Pairs

Eighty‐two mono‐or dizygotic Caucasian twins vaccinated with a 23‐valent pneumococcal vaccine, who had previously had their IgG2 antibody levels to pneumococcus type 1 determined before and after vaccination, were included in this study. Their IgG2 antibody levels were related to their G1m and G2m a...

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Veröffentlicht in:	Scandinavian journal of immunology 1994-08, Vol.40 (2), p.251-256
Hauptverfasser:	KONRADSEN, H. B., OXELIUS, V.‐A., HAHN‐ZORIC, M., HANSON, L. Å.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies, Bacterial - blood Antibodies, Bacterial - genetics Antibody Affinity - genetics Enzyme-Linked Immunosorbent Assay Female Humans Immunoglobulin G - blood Immunoglobulin Gm Allotypes - genetics Male Phenotype Polysaccharides, Bacterial - immunology Streptococcus pneumoniae Streptococcus pneumoniae - immunology Twins, Dizygotic - genetics Twins, Monozygotic - genetics
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Zusammenfassung:	Eighty‐two mono‐or dizygotic Caucasian twins vaccinated with a 23‐valent pneumococcal vaccine, who had previously had their IgG2 antibody levels to pneumococcus type 1 determined before and after vaccination, were included in this study. Their IgG2 antibody levels were related to their G1m and G2m allotypes/phenotypes and their Gm amounts. Eight different Gm phenotypes were found and characteristically IgG2 antibody levels were related to them. G2m (n) homozygotic twins had significantly higher IgG2 levels than heterozygotic twins who had significantly higher levels than G2m (‐n) homozygotic twins (P
ISSN:	0300-9475 1365-3083
DOI:	10.1111/j.1365-3083.1994.tb03458.x