Viral interactions with the host-cell cytoskeleton: the role of retroviral proteases

A surprisingly large number of animal viruses interact with cytoskeletal elements inside infected cells at different stages of replication. For example, a viral protease is activated during assembly of murine leukemia viruses at the cell surface, which causes both the morphological conversion of ‘im...

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Veröffentlicht in:	Trends in microbiology (Regular ed.) 1994-05, Vol.2 (5), p.178-182
Hauptverfasser:	Luftig, Ronald B., Davis Lupo, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animals Cytoskeleton - metabolism Endopeptidases - physiology HIV - enzymology HIV Protease - physiology Humans Leukemia Virus, Murine - enzymology Leukemia Virus, Murine - physiology Models, Biological Virus Replication - physiology
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	A surprisingly large number of animal viruses interact with cytoskeletal elements inside infected cells at different stages of replication. For example, a viral protease is activated during assembly of murine leukemia viruses at the cell surface, which causes both the morphological conversion of ‘immature’ to ‘mature’ particles and a drastic reduction of the actin stress fiber network.
ISSN:	0966-842X 1878-4380
DOI:	10.1016/0966-842X(94)90669-6