Furo [3, 2-b] indole Derivatives. II. Synthesis and Analgesic and Anti-inflammatory Activities of 4-Alkoxycarbonyl-2-morpholinocarbonylfuro [3, 2-b] indole Derivatives

As part of a series of studies on furo [3, 2-b] indole derivatives, 4-alkoxycarbonyl-2-morpholinocarbonylfuro [3, 2-b] indole derivatives were synthesized, and their analgesic and anti-inflammatory activities were examined using the acetic acid writhing method in mice and the carrageenin edema method in rats. Some of these derivatives, particularly 4-isopropoxycarbonyl-2-morpholinocarbonyl-6-trifluoromethylfuro [3, 2-b] indole, showed pronounced pharmacological activities. The structureactivity relationships are discussed.