Neuropeptide-Y Stimulates Pituitary-Adrenal Activity in Fetal and Adult Sheep

Corticotrophin‐releasing factor (CRF) and arginine vasopressin (AVP) are the primary neuropeptides regulating the secretion of ACTH from the anterior pituitary gland during fetal and adult life. However, a number of other neuropeptides including neuropeptide‐Y (NPY) appear to modulate the activity o...

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Veröffentlicht in:	Journal of neuroendocrinology 1994-04, Vol.6 (2), p.161-166
Hauptverfasser:	Brooks, A. N., Howe, D. C., Porter, D. W. F., Naylor, A. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	ACTH Adrenocorticotropic Hormone - blood Animals Biological and medical sciences Cells, Cultured Feedback Female Fetus - physiology Fundamental and applied biological sciences. Psychology Glucocorticoids - blood Hormones and neuropeptides. Regulation Hypothalamus. Hypophysis. Epiphysis. Urophysis Injections, Intraventricular Neuropeptide Y - administration & dosage Neuropeptide Y - pharmacology NPY Pituitary Gland, Anterior - cytology Pituitary Gland, Anterior - drug effects Pituitary Gland, Anterior - metabolism Pituitary-Adrenal System - drug effects Pregnancy Sheep Stimulation, Chemical Vertebrates: endocrinology
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Beschreibung
Zusammenfassung:	Corticotrophin‐releasing factor (CRF) and arginine vasopressin (AVP) are the primary neuropeptides regulating the secretion of ACTH from the anterior pituitary gland during fetal and adult life. However, a number of other neuropeptides including neuropeptide‐Y (NPY) appear to modulate the activity of this system. The potential role of NPY in the regulation of pituitary‐adrenal function was examined in fetal and adult sheep. Administration of NPY (6.5 μg) as a bolus injection into the third cerebral ventricle of adult ewes elicited a significant (P
ISSN:	0953-8194 1365-2826
DOI:	10.1111/j.1365-2826.1994.tb00567.x