Antigen-induced conformational changes in antibodies: A problem for structural prediction and design

Recent work has shown that large conformational changes in antibodies can accompany antigen binding. These structural changes can alter dramatically the size, shape and charge distribution in the antigen-binding pocket, and may present problems for accurate modeling of antibody structures.

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Bibliographische Detailangaben
Veröffentlicht in:	Trends in Biotechnology 1994-07, Vol.12 (7), p.275-279
Hauptverfasser:	Stanfield, Robyn L., Wilson, Ian A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - chemistry Antibodies - immunology Antigen-antibody reactions, antigen-antibody complexes, antibody-complement and others. Study of affinity. Antigen presentation Antigens - immunology Biological and medical sciences Biotechnology Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Models, Molecular Molecular immunology Protein Conformation
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Beschreibung
Zusammenfassung:	Recent work has shown that large conformational changes in antibodies can accompany antigen binding. These structural changes can alter dramatically the size, shape and charge distribution in the antigen-binding pocket, and may present problems for accurate modeling of antibody structures.
ISSN:	0167-7799 1879-3096
DOI:	10.1016/0167-7799(94)90139-2