Neuroanatomical divergence between two substrains of C57BL/6J inbred mice entails differential radial-maze learning

Compared to the parental strain C57BL/6J, male mice from the mutated substrain C57BL/6JNmg show smaller hippocampal intra- and infrapyramidal mossy fiber projections and a correlated inability to master a simple spatial radial-maze task. Possibly, these two substrains differ for only one single gene...

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Veröffentlicht in:	Brain research 1994-05, Vol.644 (2), p.352-356
Hauptverfasser:	Jamot, L., Bertholet, J.-Y., Crusio, W.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anatomical correlates of behavior Animals Behavioral psychophysiology Biological and medical sciences C57BL/6J mice Eight arm radial maze Fundamental and applied biological sciences. Psychology Genotype Hippocampus Hippocampus - anatomy & histology Hippocampus - physiology Inbred strain Intra- and infrapyramidal mossy fiber Learning - physiology Male Mice Mice, Inbred C57BL Mutation Phenotype Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Pyramidal Cells - physiology Space life sciences Space Perception - physiology Spatial learning Species Specificity
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Zusammenfassung:	Compared to the parental strain C57BL/6J, male mice from the mutated substrain C57BL/6JNmg show smaller hippocampal intra- and infrapyramidal mossy fiber projections and a correlated inability to master a simple spatial radial-maze task. Possibly, these two substrains differ for only one single gene, making them a valuable model to investigate the physiological pathways leading from genotype to neurobehavioral phenotype.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(94)91703-5