Expression of mRNA for the N-methyl-D-aspartate (NMDAR1) receptor by the enteric neurons of the rat

In this study, in situ hybridization techniques were employed to map the distribution of enteric neurons which express mRNA for the glutamate N-methyl-D-aspartate receptor 1 (NMDAR1). We hybridized tissue sections from the stomach, duodenum, ileum and descending colon of adult rats with a 1.43-kB ri...

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Veröffentlicht in:	Neuroscience letters 1994-03, Vol.170 (1), p.87-90
Hauptverfasser:	BURNS, G. A, STEPHENS, K. E, BENSON, J. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoradiography Biological and medical sciences Brain Chemistry - physiology Enteric Nervous System - cytology Enteric Nervous System - metabolism Fundamental and applied biological sciences. Psychology In Situ Hybridization Intestine. Mesentery Neurons - metabolism Plasmids Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - biosynthesis RNA, Messenger - biosynthesis Vertebrates: digestive system
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Beschreibung
Zusammenfassung:	In this study, in situ hybridization techniques were employed to map the distribution of enteric neurons which express mRNA for the glutamate N-methyl-D-aspartate receptor 1 (NMDAR1). We hybridized tissue sections from the stomach, duodenum, ileum and descending colon of adult rats with a 1.43-kB riboprobe cleaved from a clone of the NMDA receptor. Enteric neurons expressing the mRNA were found in both myenteric and submucosal ganglia at each of the sampling sites. Possible functions of NMDA receptors on enteric neurons are discussed.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(94)90245-3