Distribution and sub-cellular localization of drug metabolizing enzymes in the skin

SUMMARY The distribution and sub‐cellular localization of cytochrome P‐450‐dependent mono‐oxygenase activity in the skin of adult hairless mice has been investigated using ethoxycoumarin, ethoxyresorufin and benzpyrene as substrates. Highest levels of mono‐oxygenase activity per unit area of skin we...

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Veröffentlicht in:	British journal of dermatology (1951) 1985-12, Vol.113 (6), p.713-721
Hauptverfasser:	FINNEN, M.J., HERDMAN, M.L., SHUSTER, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	7-Alkoxycoumarin O-Dealkylase Animals Aryl Hydrocarbon Hydroxylases - metabolism Benz(a)Anthracenes - pharmacology Biological and medical sciences Enzyme Induction - drug effects Liver - enzymology Male Medical sciences Mice Mice, Hairless Microscopy, Electron Microsomes - ultrastructure Oxygenases - metabolism Pharmacology. Drug treatments Skin - enzymology Skin, nail, hair, dermoskeleton Subcellular Fractions - enzymology
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Zusammenfassung:	SUMMARY The distribution and sub‐cellular localization of cytochrome P‐450‐dependent mono‐oxygenase activity in the skin of adult hairless mice has been investigated using ethoxycoumarin, ethoxyresorufin and benzpyrene as substrates. Highest levels of mono‐oxygenase activity per unit area of skin were found in the dermis, both before and after induction with benzanthracene. Subcellularly, mono‐oxygenase activity was predominantly microsomal and, prior to induction, located entirely in the smooth microsomal fraction.
ISSN:	0007-0963 1365-2133
DOI:	10.1111/j.1365-2133.1985.tb02407.x