Postmortem brains reveal similar but not identical amyloid precursor protein-like immunoreactivity in Alzheimer compared with other dementias
Concentrations of amyloid precursor protein (APP)-like immunoreactivity (APPLIR) have been determined by Western blotting in a soluble fraction and two membrane fractions of two areas of brain cortex from patients with Alzheimer's disease (AD) and other dementias. There were no significant diff...
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| Veröffentlicht in: | Brain research 1994-05, Vol.644 (2), p.347-351 |
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| container_title | Brain research |
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| creator | Webster, M.-T. Francis, P.T. Procter, A.W. Stratmann, G.C. Doshi, R. Mann, D.M.A. Bowen, D.M. |
| description | Concentrations of amyloid precursor protein (APP)-like immunoreactivity (APPLIR) have been determined by Western blotting in a soluble fraction and two membrane fractions of two areas of brain cortex from patients with Alzheimer's disease (AD) and other dementias. There were no significant differences between AD and other cases in species with the Kunitz protease inhibitor domain. However, the total soluble APPLIR was higher in AD and it was hypothesized that this relates to cholinergic hypoactivity. |
| doi_str_mv | 10.1016/0006-8993(94)91702-7 |
| format | Article |
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There were no significant differences between AD and other cases in species with the Kunitz protease inhibitor domain. However, the total soluble APPLIR was higher in AD and it was hypothesized that this relates to cholinergic hypoactivity.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(94)91702-7</identifier><identifier>PMID: 8050048</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer Disease - immunology ; Alzheimer Disease - pathology ; Amyloid beta-Protein Precursor - immunology ; Amyloid beta-Protein Precursor - metabolism ; Amyloid precursor protein ; Anti-β/A4 antibody ; Autolysis ; Biological and medical sciences ; Blotting, Western ; Brain autolysis ; Brain fraction ; Cerebral Cortex - pathology ; Coma ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dementia - immunology ; Dementia - pathology ; Female ; Human brain ; Humans ; Male ; Medical sciences ; Neurology ; Trypsin Inhibitors - immunology ; Trypsin Inhibitors - metabolism ; Western blotting</subject><ispartof>Brain research, 1994-05, Vol.644 (2), p.347-351</ispartof><rights>1994 Elsevier Science B.V. All rights reserved</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-48457fb60510792a6a53f0a9ab6eef2ee888ec687eb0403c2c7d969dee8735c93</citedby><cites>FETCH-LOGICAL-c417t-48457fb60510792a6a53f0a9ab6eef2ee888ec687eb0403c2c7d969dee8735c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(94)91702-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4056129$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8050048$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Webster, M.-T.</creatorcontrib><creatorcontrib>Francis, P.T.</creatorcontrib><creatorcontrib>Procter, A.W.</creatorcontrib><creatorcontrib>Stratmann, G.C.</creatorcontrib><creatorcontrib>Doshi, R.</creatorcontrib><creatorcontrib>Mann, D.M.A.</creatorcontrib><creatorcontrib>Bowen, D.M.</creatorcontrib><title>Postmortem brains reveal similar but not identical amyloid precursor protein-like immunoreactivity in Alzheimer compared with other dementias</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Concentrations of amyloid precursor protein (APP)-like immunoreactivity (APPLIR) have been determined by Western blotting in a soluble fraction and two membrane fractions of two areas of brain cortex from patients with Alzheimer's disease (AD) and other dementias. There were no significant differences between AD and other cases in species with the Kunitz protease inhibitor domain. However, the total soluble APPLIR was higher in AD and it was hypothesized that this relates to cholinergic hypoactivity.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - immunology</subject><subject>Alzheimer Disease - pathology</subject><subject>Amyloid beta-Protein Precursor - immunology</subject><subject>Amyloid beta-Protein Precursor - metabolism</subject><subject>Amyloid precursor protein</subject><subject>Anti-β/A4 antibody</subject><subject>Autolysis</subject><subject>Biological and medical sciences</subject><subject>Blotting, Western</subject><subject>Brain autolysis</subject><subject>Brain fraction</subject><subject>Cerebral Cortex - pathology</subject><subject>Coma</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Dementia - immunology</subject><subject>Dementia - pathology</subject><subject>Female</subject><subject>Human brain</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Trypsin Inhibitors - immunology</subject><subject>Trypsin Inhibitors - metabolism</subject><subject>Western blotting</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcuO1DAQRSMEGnoG_gAkLxAaFgE7cfzYjDQa8ZJGggWsLcepqAviuLGdRs0_8M84dKuXsLJd99ZVuU5VPWP0NaNMvKGUilpp3V5r_kozSZtaPqg2TMmmFg2nD6vN2fK4ukzpW3m2raYX1YWiHaVcbarfn0PKPsQMnvTR4pxIhD3YiST0ONlI-iWTOWSCA8wZXVGsP0wBB7KL4JaYQiy3kAHnesLvQND7ZQ4RrMu4x3wgOJPb6dcW0EMkLvidjTCQn5i3JORtqQ3g12ybnlSPRjsleHo6r6qv795-uftQ3396__Hu9r52nMlcc8U7OfaCdoxK3Vhhu3akVtteAIwNgFIKnFASespp6xonBy30UATZdk63V9XLY24Z_McCKRuPycE02RnCkowUgnVNq_5rZEIzpWlXjPxodDGkFGE0u4jexoNh1Ky4zMrCrCyM5uYvLiNL2_NT_tJ7GM5NJz5Ff3HSbSqrH6OdHaazjdNOsGb9z83RBmVpe4RokkOYHQxYGGUzBPz3HH8Az620qg</recordid><startdate>19940502</startdate><enddate>19940502</enddate><creator>Webster, M.-T.</creator><creator>Francis, P.T.</creator><creator>Procter, A.W.</creator><creator>Stratmann, G.C.</creator><creator>Doshi, R.</creator><creator>Mann, D.M.A.</creator><creator>Bowen, D.M.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19940502</creationdate><title>Postmortem brains reveal similar but not identical amyloid precursor protein-like immunoreactivity in Alzheimer compared with other dementias</title><author>Webster, M.-T. ; Francis, P.T. ; Procter, A.W. ; Stratmann, G.C. ; Doshi, R. ; Mann, D.M.A. ; Bowen, D.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-48457fb60510792a6a53f0a9ab6eef2ee888ec687eb0403c2c7d969dee8735c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - immunology</topic><topic>Alzheimer Disease - pathology</topic><topic>Amyloid beta-Protein Precursor - immunology</topic><topic>Amyloid beta-Protein Precursor - metabolism</topic><topic>Amyloid precursor protein</topic><topic>Anti-β/A4 antibody</topic><topic>Autolysis</topic><topic>Biological and medical sciences</topic><topic>Blotting, Western</topic><topic>Brain autolysis</topic><topic>Brain fraction</topic><topic>Cerebral Cortex - pathology</topic><topic>Coma</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Dementia - immunology</topic><topic>Dementia - pathology</topic><topic>Female</topic><topic>Human brain</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Trypsin Inhibitors - immunology</topic><topic>Trypsin Inhibitors - metabolism</topic><topic>Western blotting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Webster, M.-T.</creatorcontrib><creatorcontrib>Francis, P.T.</creatorcontrib><creatorcontrib>Procter, A.W.</creatorcontrib><creatorcontrib>Stratmann, G.C.</creatorcontrib><creatorcontrib>Doshi, R.</creatorcontrib><creatorcontrib>Mann, D.M.A.</creatorcontrib><creatorcontrib>Bowen, D.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Webster, M.-T.</au><au>Francis, P.T.</au><au>Procter, A.W.</au><au>Stratmann, G.C.</au><au>Doshi, R.</au><au>Mann, D.M.A.</au><au>Bowen, D.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postmortem brains reveal similar but not identical amyloid precursor protein-like immunoreactivity in Alzheimer compared with other dementias</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1994-05-02</date><risdate>1994</risdate><volume>644</volume><issue>2</issue><spage>347</spage><epage>351</epage><pages>347-351</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Concentrations of amyloid precursor protein (APP)-like immunoreactivity (APPLIR) have been determined by Western blotting in a soluble fraction and two membrane fractions of two areas of brain cortex from patients with Alzheimer's disease (AD) and other dementias. There were no significant differences between AD and other cases in species with the Kunitz protease inhibitor domain. However, the total soluble APPLIR was higher in AD and it was hypothesized that this relates to cholinergic hypoactivity.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>8050048</pmid><doi>10.1016/0006-8993(94)91702-7</doi><tpages>5</tpages></addata></record> |
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| ispartof | Brain research, 1994-05, Vol.644 (2), p.347-351 |
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| subjects | Aged Aged, 80 and over Alzheimer Disease - immunology Alzheimer Disease - pathology Amyloid beta-Protein Precursor - immunology Amyloid beta-Protein Precursor - metabolism Amyloid precursor protein Anti-β/A4 antibody Autolysis Biological and medical sciences Blotting, Western Brain autolysis Brain fraction Cerebral Cortex - pathology Coma Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia - immunology Dementia - pathology Female Human brain Humans Male Medical sciences Neurology Trypsin Inhibitors - immunology Trypsin Inhibitors - metabolism Western blotting |
| title | Postmortem brains reveal similar but not identical amyloid precursor protein-like immunoreactivity in Alzheimer compared with other dementias |
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