Postmortem brains reveal similar but not identical amyloid precursor protein-like immunoreactivity in Alzheimer compared with other dementias

Postmortem brains reveal similar but not identical amyloid precursor protein-like immunoreactivity in Alzheimer compared with other dementias

Concentrations of amyloid precursor protein (APP)-like immunoreactivity (APPLIR) have been determined by Western blotting in a soluble fraction and two membrane fractions of two areas of brain cortex from patients with Alzheimer's disease (AD) and other dementias. There were no significant diff...

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Veröffentlicht in:Brain research 1994-05, Vol.644 (2), p.347-351
Hauptverfasser: Webster, M.-T., Francis, P.T., Procter, A.W., Stratmann, G.C., Doshi, R., Mann, D.M.A., Bowen, D.M.
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Aged, 80 and over
Alzheimer Disease - immunology
Alzheimer Disease - pathology
Amyloid beta-Protein Precursor - immunology
Amyloid beta-Protein Precursor - metabolism
Amyloid precursor protein
Anti-β/A4 antibody
Autolysis
Biological and medical sciences
Blotting, Western
Brain autolysis
Brain fraction
Cerebral Cortex - pathology
Coma
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dementia - immunology
Dementia - pathology
Female
Human brain
Humans
Male
Medical sciences
Neurology
Trypsin Inhibitors - immunology
Trypsin Inhibitors - metabolism
Western blotting
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Zusammenfassung:Concentrations of amyloid precursor protein (APP)-like immunoreactivity (APPLIR) have been determined by Western blotting in a soluble fraction and two membrane fractions of two areas of brain cortex from patients with Alzheimer's disease (AD) and other dementias. There were no significant differences between AD and other cases in species with the Kunitz protease inhibitor domain. However, the total soluble APPLIR was higher in AD and it was hypothesized that this relates to cholinergic hypoactivity.
ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(94)91702-7