Transferrin receptor: its biological significance

Since iron metabolism and the transferrin receptor (TR) has been reviewed in detail recently, this work will primarily concentrate on the following areas: role of the TR in cellular iron delivery, the nature of the signal(s) necessary to induce receptor endocytosis, involvement of the TR in regulation of cell proliferation, and the possible clinical role for the TR in anti-tumor therapy. Other areas of TR characterization such as structure, biosynthesis, intracellular iron metabolism, and receptor turnover will be touched on only briefly.