Selective RNA editing and subunit assembly of native glutamate receptors

RNA editing and subunit assembly of ionotropic glutamate receptors (GIuRs) were examined in an oligodendrocyte progenitor cell line, CG4, which expresses GluR2-GluR4, GluR6, GluR7, KA1, and KA2. AMPA-evoked currents rapidly desensitize, whereas kainate-evoked currents contain a steady-state componen...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 1994-07, Vol.13 (1), p.131-147
Hauptverfasser:	Puchalski, Ralph B., Louis, Jean-Claude, Brose, Nils, Traynelis, Stephen F., Egebjerg, Jan, Kukekov, Valery, J.Wenthold, Robert, Rogers, Scott W., Lin, Fan, Moran, Thomas, Morrison, John H., Heinemann, Stephen F.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology Animals Arginine Base Sequence Cell Line Cerebral Cortex - cytology Codon Electric Conductivity Glutamates - pharmacology Glutamic Acid Humans Immunosorbent Techniques Ion Channels - drug effects Ion Channels - physiology Kainic Acid - pharmacology Molecular Sequence Data Oligodendroglia - drug effects Oligodendroglia - physiology Polymerase Chain Reaction Rats Receptors, Glutamate - genetics Receptors, Glutamate - physiology RNA - chemistry RNA Editing RNA Splicing Stem Cells - physiology
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Zusammenfassung:	RNA editing and subunit assembly of ionotropic glutamate receptors (GIuRs) were examined in an oligodendrocyte progenitor cell line, CG4, which expresses GluR2-GluR4, GluR6, GluR7, KA1, and KA2. AMPA-evoked currents rapidly desensitize, whereas kainate-evoked currents contain a steady-state component with a nearly linear current-voltage relation and a fast desensitizing component that is inwardly rectifying. The Q/R site is edited >95% to the arginine codon in GluR2(Q607) mRNA, and
ISSN:	0896-6273 1097-4199
DOI:	10.1016/0896-6273(94)90464-2