N-methyl-D-aspartic acid receptor structure and function

The properties of N-methyl-D-aspartic acid (NMDA) receptors are examined using the techniques of biophysics and molecular biology and are placed in a physiological context. Responses at NMDA receptors have the unusual properties for a ligand-gated ion channel of strong voltage dependence and high ca...

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Veröffentlicht in:	Physiological reviews 1994-07, Vol.74 (3), p.723-760
Hauptverfasser:	MCBAIN, C. J, MAYER, M. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Aminoacid receptors (glycine, glutamate, gaba) Animals Biological and medical sciences Cell receptors Cell structures and functions Cellular biology Cytoskeleton - metabolism Fundamental and applied biological sciences. Psychology Humans Ions Kinetics Methyl aspartate Molecular and cellular biology Molecular Sequence Data Nervous system Neurotransmitter receptors Physiological aspects Receptors, N-Methyl-D-Aspartate - chemistry Receptors, N-Methyl-D-Aspartate - genetics Receptors, N-Methyl-D-Aspartate - physiology Recombinant Proteins Second Messenger Systems Structure-Activity Relationship Synaptic Transmission
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Beschreibung
Zusammenfassung:	The properties of N-methyl-D-aspartic acid (NMDA) receptors are examined using the techniques of biophysics and molecular biology and are placed in a physiological context. Responses at NMDA receptors have the unusual properties for a ligand-gated ion channel of strong voltage dependence and high calcium2plus permeability.
ISSN:	0031-9333 1522-1210
DOI:	10.1152/physrev.1994.74.3.723