The neurotropic activity of a structural analog of ACTH(5–7)

The tripeptide glutamyl-arginyl-proline (ERP) mimicking some structural features of the N-terminal fragment of adrenocorticotropic hormone, ACTH(5–7), has been synthesized. In contrast with ACTH fragments, ERP (0.015–0.15 mg/kg; intraperitoneal injection) hindered the formation of food-reinforced ta...

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Veröffentlicht in:	Regulatory peptides 1994-04, Vol.51 (1), p.49-54
Hauptverfasser:	Ashmarin, I.P., Levitskaya, N.G., Antonova, L.V., Nezavibatko, V.N., Alfeeva, L.Yu, Dubinin, V.A., Golubovich, V.P., Ponomareva-Stepnaya, M.A., Kamensky, A.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	ACTH/MSH-like peptide Adrenocorticotropic Hormone - metabolism Adrenocorticotropic Hormone - pharmacology Amino Acid Sequence Analysis of Variance Animals Avoidance Learning - drug effects Behavior Behavior, Animal - drug effects Injections, Intraperitoneal Learning Male Molecular Sequence Data Motor Activity - drug effects Oligopeptides - chemical synthesis Oligopeptides - pharmacology Rats Structure-Activity Relationship
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Zusammenfassung:	The tripeptide glutamyl-arginyl-proline (ERP) mimicking some structural features of the N-terminal fragment of adrenocorticotropic hormone, ACTH(5–7), has been synthesized. In contrast with ACTH fragments, ERP (0.015–0.15 mg/kg; intraperitoneal injection) hindered the formation of food-reinforced task in adult albino male rats. Besides, ERP caused a rapid inhibition of the previously formed conditioned task. Similar doses of ERP changed orientative-trying reaction and emotional behavior in rats in the ‘open field’ test. ERP at a dose of 0.15 mg/kg administered prior to the injection of 0.5 mg/kg ACTH(1–39) prevented increases in locomotor activity normally induced by this hormone. Thus, ERP disrupts learning, impairs performance of acquired task and blocks behavioral effects of ACTH and its fragments.
ISSN:	0167-0115 1873-1686
DOI:	10.1016/0167-0115(94)90134-1